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- W2061042944 abstract "We derive the equation of state of DNA under tension that features a loop. Such loops occur transiently during DNA condensation in the presence of multivalent ions or permanently through sliding protein linkers such as condensin. The force-extension relation of such looped-DNA modeled as a wormlike chain is calculated via path integration in the semiclassical limit. This allows us to rigorously determine the high stretching asymptotics. Notably the functional form of the force-extension curve resembles that of straight DNA, yet with a strongly renormalized apparent persistence length. We also present analogous results for DNA under tension with several protein-induced kinks and/or loops. That means that the experimentally extracted single-molecule elasticity does not necessarily only reflect the bare DNA stiffness, but can also contain additional contributions that depend on the overall chain conformation and length." @default.
- W2061042944 created "2016-06-24" @default.
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- W2061042944 date "2007-01-16" @default.
- W2061042944 modified "2023-10-14" @default.
- W2061042944 title "Equation of state of looped DNA" @default.
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- W2061042944 doi "https://doi.org/10.1103/physreve.75.011913" @default.
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