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- W2061050235 endingPage "25" @default.
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- W2061050235 abstract "There are currently more than 600 diseases characterized as affecting the central nervous system (CNS) which inflict neural damage. Unfortunately, few of these conditions have effective treatments available. Although significant efforts have been put into developing new therapeutics, drugs which were promising in the developmental phase have high attrition rates in late stage clinical trials. These failures could be circumvented if current 2D in vitro and in vivo models were improved. 3D, tissue-engineered in vitro systems can address this need and enhance clinical translation through two approaches: (1) bottom-up, and (2) top-down (developmental/regenerative) strategies to reproduce the structure and function of human tissues. Critical challenges remain including biomaterials capable of matching the mechanical properties and extracellular matrix (ECM) composition of neural tissues, compartmentalized scaffolds that support heterogeneous tissue architectures reflective of brain organization and structure, and robust functional assays for in vitro tissue validation. The unique design parameters defined by the complex physiology of the CNS for construction and validation of 3D in vitro neural systems are reviewed here." @default.
- W2061050235 created "2016-06-24" @default.
- W2061050235 creator A5057628028 @default.
- W2061050235 creator A5057871048 @default.
- W2061050235 creator A5058372263 @default.
- W2061050235 creator A5064001753 @default.
- W2061050235 date "2015-02-01" @default.
- W2061050235 modified "2023-10-12" @default.
- W2061050235 title "3D in vitro modeling of the central nervous system" @default.
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