Matches in SemOpenAlex for { <https://semopenalex.org/work/W2061050909> ?p ?o ?g. }
- W2061050909 endingPage "1244" @default.
- W2061050909 startingPage "1235" @default.
- W2061050909 abstract "Taste receptors on the tongue communicate information to the brain about the nutrient content or potential toxicity of ingested foods. However, recent research has now shown that taste receptors are also expressed far beyond the tongue, from the airway and gastrointestinal epithelia to the pancreas and brain. The functions of many of these so-called extraoral taste receptors remain unknown, but emerging basic science and clinical evidence suggests that bitter and sweet taste receptors in the airway are important in sensing bacteria and regulating innate immunity. This review focuses on the role of bitter and sweet taste receptors in human airway innate immunity and the potential clinical relevance to airway infections. The T2R38 bitter taste receptor in sinonasal cilia detects bitter bacterial quorum-sensing molecules and activates nitric oxide-dependent innate immune responses. Polymorphisms that underlie T2R38 functionality also appear to be involved in susceptibility to upper respiratory infection and chronic rhinosinusitis (CRS). Bitter and sweet receptors in specialized sinonasal solitary chemosensory cells control antimicrobial peptide secretion, which may have important implications for airway infections in CRS patients as well as patients with diabetes mellitus. Future research on taste receptors in the airway has tremendous potential to identify immune mechanisms involved in host-pathogen interactions and thus reveal novel therapeutic targets." @default.
- W2061050909 created "2016-06-24" @default.
- W2061050909 creator A5040022220 @default.
- W2061050909 creator A5077476688 @default.
- W2061050909 date "2014-11-13" @default.
- W2061050909 modified "2023-10-08" @default.
- W2061050909 title "Bitter and sweet taste receptors in the respiratory epithelium in health and disease" @default.
- W2061050909 cites W136720212 @default.
- W2061050909 cites W144194649 @default.
- W2061050909 cites W1495523582 @default.
- W2061050909 cites W1496715675 @default.
- W2061050909 cites W1542303954 @default.
- W2061050909 cites W1903990541 @default.
- W2061050909 cites W1905079993 @default.
- W2061050909 cites W1944653288 @default.
- W2061050909 cites W1963718985 @default.
- W2061050909 cites W1964050294 @default.
- W2061050909 cites W1965212424 @default.
- W2061050909 cites W1965859904 @default.
- W2061050909 cites W1968558201 @default.
- W2061050909 cites W1973285563 @default.
- W2061050909 cites W1976133370 @default.
- W2061050909 cites W1978429003 @default.
- W2061050909 cites W1978686145 @default.
- W2061050909 cites W1980509967 @default.
- W2061050909 cites W1983881012 @default.
- W2061050909 cites W1985101496 @default.
- W2061050909 cites W1987703588 @default.
- W2061050909 cites W1990344121 @default.
- W2061050909 cites W1999355550 @default.
- W2061050909 cites W2002420804 @default.
- W2061050909 cites W2002676268 @default.
- W2061050909 cites W2003093251 @default.
- W2061050909 cites W2003544664 @default.
- W2061050909 cites W2003977878 @default.
- W2061050909 cites W2006829169 @default.
- W2061050909 cites W2016948259 @default.
- W2061050909 cites W2023261922 @default.
- W2061050909 cites W2027635017 @default.
- W2061050909 cites W2027899459 @default.
- W2061050909 cites W2031802002 @default.
- W2061050909 cites W2035040196 @default.
- W2061050909 cites W2036927671 @default.
- W2061050909 cites W2038803905 @default.
- W2061050909 cites W2039330081 @default.
- W2061050909 cites W2041722631 @default.
- W2061050909 cites W2046325265 @default.
- W2061050909 cites W2047651536 @default.
- W2061050909 cites W2047988968 @default.
- W2061050909 cites W2052099974 @default.
- W2061050909 cites W2054237603 @default.
- W2061050909 cites W2056694916 @default.
- W2061050909 cites W2057808457 @default.
- W2061050909 cites W2059117845 @default.
- W2061050909 cites W2059488198 @default.
- W2061050909 cites W2059931449 @default.
- W2061050909 cites W2061882045 @default.
- W2061050909 cites W2062212264 @default.
- W2061050909 cites W2064829419 @default.
- W2061050909 cites W2065967553 @default.
- W2061050909 cites W2069165085 @default.
- W2061050909 cites W2070656125 @default.
- W2061050909 cites W2074779228 @default.
- W2061050909 cites W207997673 @default.
- W2061050909 cites W2080972001 @default.
- W2061050909 cites W2081364727 @default.
- W2061050909 cites W2081485204 @default.
- W2061050909 cites W2082229377 @default.
- W2061050909 cites W2084032974 @default.
- W2061050909 cites W2085312606 @default.
- W2061050909 cites W2095499340 @default.
- W2061050909 cites W2096921233 @default.
- W2061050909 cites W2099039337 @default.
- W2061050909 cites W2107856368 @default.
- W2061050909 cites W2108903976 @default.
- W2061050909 cites W2111580238 @default.
- W2061050909 cites W2114742945 @default.
- W2061050909 cites W2119572285 @default.
- W2061050909 cites W2120877754 @default.
- W2061050909 cites W2122060463 @default.
- W2061050909 cites W2122283286 @default.
- W2061050909 cites W2123876380 @default.
- W2061050909 cites W2133302347 @default.
- W2061050909 cites W2137263528 @default.
- W2061050909 cites W2139177655 @default.
- W2061050909 cites W2142554957 @default.
- W2061050909 cites W2144827439 @default.
- W2061050909 cites W2146769602 @default.
- W2061050909 cites W2149760554 @default.
- W2061050909 cites W2150028083 @default.
- W2061050909 cites W2160968619 @default.
- W2061050909 cites W2163903769 @default.
- W2061050909 cites W2164440959 @default.
- W2061050909 cites W2168671905 @default.
- W2061050909 cites W2168755417 @default.
- W2061050909 cites W2170342544 @default.
- W2061050909 cites W2172061376 @default.
- W2061050909 cites W2184995483 @default.