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- W2061051002 abstract "Activation of the archetypal Transient Receptor Potential (TRP) channel, which is essential for Drosophila phototransduction, depends on a phospholipase C (PLC). However, the precise mechanism linking PLC to the gating of TRP has been elusive. In this issue of Neuron, Leung et al. provide compelling evidence that a diacylglycerol (DAG) lipase (INAE), acting downstream of the PLC, is essential for opening TRP. These results strongly support the model that a DAG metabolite is critical for TRP activation and suggest that mammalian DAG lipases may play similar roles." @default.
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- W2061051002 date "2008-06-01" @default.
- W2061051002 modified "2023-10-18" @default.
- W2061051002 title "In Search of the Holy Grail for Drosophila TRP" @default.
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- W2061051002 doi "https://doi.org/10.1016/j.neuron.2008.06.006" @default.
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