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- W206105467 abstract "Ascorbate pretreatment destroys stereospecific binding (SSB) of opioids by brain membrane preparations. At 22°, the loss of SSB only occurs in the presence of oxygen, but inhibitors of oxidative enzymes do not retard the destruction of SSB. Ascorbate catalyzes lipid peroxidation by a free radical mechanism, and some metal ions, chelating agents and lipid antioxidants protect against the destructive effects of ascorbate. The results suggest that a lipid component of the neuronal membrane contributes to ligand binding by the opiate receptor." @default.
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- W206105467 date "1980-01-01" @default.
- W206105467 modified "2023-09-23" @default.
- W206105467 title "ASCORBATE DESTRUCTION OF OPIOID STEREOSPECIFIC BINDING; EVIDENCE FOR RECEPTOR REGULATION BY MEMBRANE LIPID" @default.
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- W206105467 doi "https://doi.org/10.1016/b978-0-08-025488-3.50019-2" @default.
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