FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2061064811> ?p ?o ?g. }

• W2061064811 endingPage "670" @default.
• W2061064811 startingPage "665" @default.
• W2061064811 abstract "Jejunoileal bypass (JIB) is a weight loss procedure in which malabsorption is produced by connecting a short length of proximal jejunum to the distal ileum. Because 90% of the small intestine is bypassed, it may have impact on the dose–concentration response of oral cyclosporine (CsA). The authors characterized the dose-adjusted blood concentrations of CsA obtained 2 hours (C2) after oral microemulsion CsA (ME-CsA) in a liver transplant (LTx) subject with an intact JIB, as compared with those from seven LTx controls without JIB. The biliary reconstruction involved choledochocholedochostomy without external drainage in all patients. ME-CsA was administered via a nasogastric tube within 24 hours after graft reperfusion. Oral fluconazole was given prophylactically to the study subject only for 6 days after LTx. During the first week after LTx, the dose-adjusted C2 (mean ± SD) for the study subject and for controls was 53 ± 10 and 106 ± 47 ng/mL, respectively (P < 0.001). The corresponding value during the period from day 7 to day 107 was 105 ± 40 and 257 ± 86 ng/mL, respectively (P < 0.001). Multiple linear regression revealed that dosage, days after LTx, and the presence of a JIB were all independent predictors of C2 (R2 = 0.798, P = 0.037). Lack of bile resulting in malabsorption of ME-CsA was not thought to be significant contributor to her low dose-adjusted C2 because there was no external bile drainage and a portion of terminal ileum, where most bile acid reabsorption occurred, was still available after JIB. The fact that fluconazole failed to increase the dose-adjusted C2 in the study subject supports that enteric clearance of CsA may become clinically unimportant after JIB. Therefore, the low dose-adjusted C2 is most likely explained by the reduced bowel length and associated absorptive surface area after JIB. In conclusion, patients with JIB may require higher doses of ME-CsA." @default.
• W2061064811 created "2016-06-24" @default.
• W2061064811 creator A5001930460 @default.
• W2061064811 creator A5009055760 @default.
• W2061064811 creator A5076326820 @default.
• W2061064811 creator A5089098946 @default.
• W2061064811 date "2003-12-01" @default.
• W2061064811 modified "2023-10-11" @default.
• W2061064811 title "Dose-Adjusted Cyclosporine C2 in a Patient with Jejunoileal Bypass as Compared to Seven Other Liver Transplant Recipients" @default.
• W2061064811 cites W1968896470 @default.
• W2061064811 cites W1972544028 @default.
• W2061064811 cites W1973080555 @default.
• W2061064811 cites W1976927311 @default.
• W2061064811 cites W1978777034 @default.
• W2061064811 cites W1983297225 @default.
• W2061064811 cites W1984601088 @default.
• W2061064811 cites W1992303861 @default.
• W2061064811 cites W1998071452 @default.
• W2061064811 cites W2015500397 @default.
• W2061064811 cites W2015693061 @default.
• W2061064811 cites W2018857408 @default.
• W2061064811 cites W2021544053 @default.
• W2061064811 cites W2022713088 @default.
• W2061064811 cites W2078006847 @default.
• W2061064811 cites W2081101493 @default.
• W2061064811 cites W2082453607 @default.
• W2061064811 cites W2102724745 @default.
• W2061064811 cites W2113851602 @default.
• W2061064811 cites W2136066865 @default.
• W2061064811 cites W2136517919 @default.
• W2061064811 cites W2169850270 @default.
• W2061064811 cites W2318111831 @default.
• W2061064811 cites W2413397161 @default.
• W2061064811 cites W2570459806 @default.
• W2061064811 doi "https://doi.org/10.1097/00007691-200312000-00004" @default.
• W2061064811 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14639052" @default.
• W2061064811 hasPublicationYear "2003" @default.
• W2061064811 type Work @default.
• W2061064811 sameAs 2061064811 @default.
• W2061064811 citedByCount "22" @default.
• W2061064811 countsByYear W20610648112012 @default.
• W2061064811 countsByYear W20610648112013 @default.
• W2061064811 countsByYear W20610648112016 @default.
• W2061064811 countsByYear W20610648112018 @default.
• W2061064811 countsByYear W20610648112019 @default.
• W2061064811 countsByYear W20610648112020 @default.
• W2061064811 countsByYear W20610648112021 @default.
• W2061064811 countsByYear W20610648112022 @default.
• W2061064811 countsByYear W20610648112023 @default.
• W2061064811 crossrefType "journal-article" @default.
• W2061064811 hasAuthorship W2061064811A5001930460 @default.
• W2061064811 hasAuthorship W2061064811A5009055760 @default.
• W2061064811 hasAuthorship W2061064811A5076326820 @default.
• W2061064811 hasAuthorship W2061064811A5089098946 @default.
• W2061064811 hasConcept C126322002 @default.
• W2061064811 hasConcept C126894567 @default.
• W2061064811 hasConcept C141071460 @default.
• W2061064811 hasConcept C2776366702 @default.
• W2061064811 hasConcept C2777226302 @default.
• W2061064811 hasConcept C2778925797 @default.
• W2061064811 hasConcept C2779399885 @default.
• W2061064811 hasConcept C2780439177 @default.
• W2061064811 hasConcept C3020583074 @default.
• W2061064811 hasConcept C511355011 @default.
• W2061064811 hasConcept C544821477 @default.
• W2061064811 hasConcept C71924100 @default.
• W2061064811 hasConcept C90924648 @default.
• W2061064811 hasConceptScore W2061064811C126322002 @default.
• W2061064811 hasConceptScore W2061064811C126894567 @default.
• W2061064811 hasConceptScore W2061064811C141071460 @default.
• W2061064811 hasConceptScore W2061064811C2776366702 @default.
• W2061064811 hasConceptScore W2061064811C2777226302 @default.
• W2061064811 hasConceptScore W2061064811C2778925797 @default.
• W2061064811 hasConceptScore W2061064811C2779399885 @default.
• W2061064811 hasConceptScore W2061064811C2780439177 @default.
• W2061064811 hasConceptScore W2061064811C3020583074 @default.
• W2061064811 hasConceptScore W2061064811C511355011 @default.
• W2061064811 hasConceptScore W2061064811C544821477 @default.
• W2061064811 hasConceptScore W2061064811C71924100 @default.
• W2061064811 hasConceptScore W2061064811C90924648 @default.
• W2061064811 hasIssue "6" @default.
• W2061064811 hasLocation W20610648111 @default.
• W2061064811 hasLocation W20610648112 @default.
• W2061064811 hasOpenAccess W2061064811 @default.
• W2061064811 hasPrimaryLocation W20610648111 @default.
• W2061064811 hasRelatedWork W1467338230 @default.
• W2061064811 hasRelatedWork W1964807816 @default.
• W2061064811 hasRelatedWork W1988475241 @default.
• W2061064811 hasRelatedWork W2039219625 @default.
• W2061064811 hasRelatedWork W2039472229 @default.
• W2061064811 hasRelatedWork W2056253058 @default.
• W2061064811 hasRelatedWork W2287876872 @default.
• W2061064811 hasRelatedWork W2289395671 @default.
• W2061064811 hasRelatedWork W2389734465 @default.
• W2061064811 hasRelatedWork W4286283863 @default.
• W2061064811 hasVolume "25" @default.
• W2061064811 isParatext "false" @default.
• W2061064811 isRetracted "false" @default.

• next