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• W2061083265 abstract "Human tyrosyl-DNA phosphodiesterase (TDP1) hydrolyzes the phosphodiester bond at a DNA 3'-end linked to a tyrosyl moiety and has been implicated in the repair of topoisomerase I (Top1)-DNA covalent complexes. TDP1 can also hydrolyze other 3'-end DNA alterations including 3'-phosphoglycolate and 3'-abasic sites, and exhibits 3'-nucleosidase activity indicating it may function as a general 3'-end-processing DNA repair enzyme. Here, using laser confocal microscopy, subcellular fractionation and biochemical analyses we demonstrate that a fraction of the TDP1 encoded by the nuclear TDP1 gene localizes to mitochondria. We also show that mitochondrial base excision repair depends on TDP1 activity and provide evidence that TDP1 is required for efficient repair of oxidative damage in mitochondrial DNA. Together, our findings provide evidence for TDP1 as a novel mitochondrial enzyme." @default.
• W2061083265 created "2016-06-24" @default.
• W2061083265 creator A5041856740 @default.
• W2061083265 creator A5042114293 @default.
• W2061083265 creator A5042244136 @default.
• W2061083265 creator A5057930914 @default.
• W2061083265 date "2010-11-01" @default.
• W2061083265 modified "2023-10-17" @default.
• W2061083265 title "Role of tyrosyl-DNA phosphodiesterase (TDP1) in mitochondria" @default.
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• W2061083265 doi "https://doi.org/10.1073/pnas.1009814107" @default.
• W2061083265 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2993338" @default.
• W2061083265 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21041670" @default.
• W2061083265 hasPublicationYear "2010" @default.
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