Matches in SemOpenAlex for { <https://semopenalex.org/work/W2061085352> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W2061085352 endingPage "679" @default.
- W2061085352 startingPage "672" @default.
- W2061085352 abstract "Previous attempts to prevent all the unwanted postoperative responses to major surgery with an epidural hydrophilic opioid, morphine, have not succeeded. The authors' hypothesis was that the lipophilic opioid fentanyl, infused epidurally close to the spinal-cord opioid receptors corresponding to the dermatome of the surgical incision, gives equal pain relief but attenuates postoperative hormonal and metabolic responses more effectively than does systemic fentanyl.Forty patients were randomly assigned to receive either fentanyl epidurally and saline intravenously, or fentanyl intravenously and saline epidurally, in a double-blind fashion for the first 20 h after thoracotomy. For each patient, the fentanyl infusion was titrated to the rate required for pain relief (pain score < 3, maximum 10). Postoperative changes in blood pressure, heart rate, rectal temperature, and blood concentrations of adrenocorticotrophic hormone, beta-endorphin immunoreactivity, cortisol, growth hormone, prolactin, glucose, and leukocytes were assessed.Patients reported similar median pain scores, but the epidural group required about 40% less fentanyl than the intravenous group. Four hours postoperatively, the beta-endorphin immunoreactivity concentrations were less in the epidural than in the intravenous group. Plasma cortisol increased in a similar manner in both groups within 4 h of surgery, but the increase persisted to the next morning only in patients receiving intravenous fentanyl. Adrenocorticotropin, growth hormone, and prolactin responses were similar in both groups. The postoperative hyperglycemic response, leukocytosis, and blood pressure were greater, and mean rectal temperature was lower, in the intravenous than in the epidural fentanyl group.The authors' results indicate that some aspects of the hormonal response to surgery are blocked more completely with epidural than with intravenous fentanyl. Adequate pain relief with epidural fentanyl, with a smaller mean dose, led to a smaller increase of some hormonal, metabolic, and physiologic responses after thoracotomy than in association with the adequate pain relief provided by intravenous fentanyl." @default.
- W2061085352 created "2016-06-24" @default.
- W2061085352 creator A5018593288 @default.
- W2061085352 creator A5069650608 @default.
- W2061085352 creator A5072205041 @default.
- W2061085352 creator A5080099083 @default.
- W2061085352 creator A5084535690 @default.
- W2061085352 date "1993-10-01" @default.
- W2061085352 modified "2023-10-17" @default.
- W2061085352 title "Epidural Versus Intravenous Fentanyl for Reducing Hormonal, Metabolic, and Physiologic Responses after Thoracotomy" @default.
- W2061085352 doi "https://doi.org/10.1097/00000542-199310000-00007" @default.
- W2061085352 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8214746" @default.
- W2061085352 hasPublicationYear "1993" @default.
- W2061085352 type Work @default.
- W2061085352 sameAs 2061085352 @default.
- W2061085352 citedByCount "70" @default.
- W2061085352 countsByYear W20610853522012 @default.
- W2061085352 countsByYear W20610853522014 @default.
- W2061085352 countsByYear W20610853522018 @default.
- W2061085352 countsByYear W20610853522019 @default.
- W2061085352 countsByYear W20610853522020 @default.
- W2061085352 countsByYear W20610853522021 @default.
- W2061085352 countsByYear W20610853522022 @default.
- W2061085352 crossrefType "journal-article" @default.
- W2061085352 hasAuthorship W2061085352A5018593288 @default.
- W2061085352 hasAuthorship W2061085352A5069650608 @default.
- W2061085352 hasAuthorship W2061085352A5072205041 @default.
- W2061085352 hasAuthorship W2061085352A5080099083 @default.
- W2061085352 hasAuthorship W2061085352A5084535690 @default.
- W2061085352 hasBestOaLocation W20610853521 @default.
- W2061085352 hasConcept C126322002 @default.
- W2061085352 hasConcept C141071460 @default.
- W2061085352 hasConcept C170493617 @default.
- W2061085352 hasConcept C2777389121 @default.
- W2061085352 hasConcept C2777397205 @default.
- W2061085352 hasConcept C2777953023 @default.
- W2061085352 hasConcept C2778847313 @default.
- W2061085352 hasConcept C2781063702 @default.
- W2061085352 hasConcept C2781072394 @default.
- W2061085352 hasConcept C42219234 @default.
- W2061085352 hasConcept C71924100 @default.
- W2061085352 hasConcept C84393581 @default.
- W2061085352 hasConceptScore W2061085352C126322002 @default.
- W2061085352 hasConceptScore W2061085352C141071460 @default.
- W2061085352 hasConceptScore W2061085352C170493617 @default.
- W2061085352 hasConceptScore W2061085352C2777389121 @default.
- W2061085352 hasConceptScore W2061085352C2777397205 @default.
- W2061085352 hasConceptScore W2061085352C2777953023 @default.
- W2061085352 hasConceptScore W2061085352C2778847313 @default.
- W2061085352 hasConceptScore W2061085352C2781063702 @default.
- W2061085352 hasConceptScore W2061085352C2781072394 @default.
- W2061085352 hasConceptScore W2061085352C42219234 @default.
- W2061085352 hasConceptScore W2061085352C71924100 @default.
- W2061085352 hasConceptScore W2061085352C84393581 @default.
- W2061085352 hasIssue "4" @default.
- W2061085352 hasLocation W20610853521 @default.
- W2061085352 hasLocation W20610853522 @default.
- W2061085352 hasOpenAccess W2061085352 @default.
- W2061085352 hasPrimaryLocation W20610853521 @default.
- W2061085352 hasRelatedWork W1972063073 @default.
- W2061085352 hasRelatedWork W1979925598 @default.
- W2061085352 hasRelatedWork W2047093098 @default.
- W2061085352 hasRelatedWork W2054129013 @default.
- W2061085352 hasRelatedWork W2074008392 @default.
- W2061085352 hasRelatedWork W2079890364 @default.
- W2061085352 hasRelatedWork W2080239242 @default.
- W2061085352 hasRelatedWork W2147130154 @default.
- W2061085352 hasRelatedWork W2922257811 @default.
- W2061085352 hasRelatedWork W3035057373 @default.
- W2061085352 hasVolume "79" @default.
- W2061085352 isParatext "false" @default.
- W2061085352 isRetracted "false" @default.
- W2061085352 magId "2061085352" @default.
- W2061085352 workType "article" @default.