FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2061092178> ?p ?o ?g. }

• W2061092178 endingPage "52" @default.
• W2061092178 startingPage "41" @default.
• W2061092178 abstract "The effect of the glucose analogue N-hydroxyethyl-1-deoxynojirimycin (BAY m 1099) on the activity of α-glucosidases was studied in human fibroblasts and HepG2 cells. BAY m 1099 inhibits neutral and acid α-glucosidase activities of both cell types in a dosage-dependent and reversible manner. Inhibition of endoplasmic reticulum glucosidases I and/or II is suggested by delayed processing of lysosomal (acid) α-glucosidase. Competitive inhibition of mature acid α-glucosidase leads to lysosomal accumulation of glycogen as in glycogenosis type II. There seems to be little risk, however, of inducing this storage disorder when using the drug in a dose of 50 mg per os for treatment of type II diabetes. In high doses, the drug may prove useful for studying the pathogenesis of glycogenosis type II in vitro or in animal models." @default.
• W2061092178 created "2016-06-24" @default.
• W2061092178 creator A5006790084 @default.
• W2061092178 creator A5015749919 @default.
• W2061092178 creator A5025385826 @default.
• W2061092178 date "1989-06-01" @default.
• W2061092178 modified "2023-09-25" @default.
• W2061092178 title "Effects of N-hydroxyethyl-1-deoxynojirimycin (BAY m 1099) on the activity of neutral- and acid α-glucosidases in human fibroblasts and HepG2 cells" @default.
• W2061092178 cites W1491202632 @default.
• W2061092178 cites W1507732063 @default.
• W2061092178 cites W1534281450 @default.
• W2061092178 cites W1548179157 @default.
• W2061092178 cites W1554245862 @default.
• W2061092178 cites W1599848121 @default.
• W2061092178 cites W1775749144 @default.
• W2061092178 cites W1979443014 @default.
• W2061092178 cites W1988631157 @default.
• W2061092178 cites W1999002573 @default.
• W2061092178 cites W2009070853 @default.
• W2061092178 cites W2021233703 @default.
• W2061092178 cites W2047636005 @default.
• W2061092178 cites W2070457237 @default.
• W2061092178 cites W2072585523 @default.
• W2061092178 cites W2081215329 @default.
• W2061092178 cites W2087414893 @default.
• W2061092178 cites W2088937315 @default.
• W2061092178 cites W2093003119 @default.
• W2061092178 cites W2095720325 @default.
• W2061092178 cites W2100837269 @default.
• W2061092178 cites W2126961090 @default.
• W2061092178 cites W2319264423 @default.
• W2061092178 cites W2330115723 @default.
• W2061092178 cites W2422564701 @default.
• W2061092178 doi "https://doi.org/10.1016/0009-8981(89)90148-4" @default.
• W2061092178 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2546700" @default.
• W2061092178 hasPublicationYear "1989" @default.
• W2061092178 type Work @default.
• W2061092178 sameAs 2061092178 @default.
• W2061092178 citedByCount "14" @default.
• W2061092178 countsByYear W20610921782012 @default.
• W2061092178 countsByYear W20610921782015 @default.
• W2061092178 crossrefType "journal-article" @default.
• W2061092178 hasAuthorship W2061092178A5006790084 @default.
• W2061092178 hasAuthorship W2061092178A5015749919 @default.
• W2061092178 hasAuthorship W2061092178A5025385826 @default.
• W2061092178 hasConcept C158617107 @default.
• W2061092178 hasConcept C181199279 @default.
• W2061092178 hasConcept C185592680 @default.
• W2061092178 hasConcept C202751555 @default.
• W2061092178 hasConcept C2776584326 @default.
• W2061092178 hasConcept C2777499176 @default.
• W2061092178 hasConcept C2780216420 @default.
• W2061092178 hasConcept C55493867 @default.
• W2061092178 hasConcept C86803240 @default.
• W2061092178 hasConceptScore W2061092178C158617107 @default.
• W2061092178 hasConceptScore W2061092178C181199279 @default.
• W2061092178 hasConceptScore W2061092178C185592680 @default.
• W2061092178 hasConceptScore W2061092178C202751555 @default.
• W2061092178 hasConceptScore W2061092178C2776584326 @default.
• W2061092178 hasConceptScore W2061092178C2777499176 @default.
• W2061092178 hasConceptScore W2061092178C2780216420 @default.
• W2061092178 hasConceptScore W2061092178C55493867 @default.
• W2061092178 hasConceptScore W2061092178C86803240 @default.
• W2061092178 hasIssue "1" @default.
• W2061092178 hasLocation W20610921781 @default.
• W2061092178 hasLocation W20610921782 @default.
• W2061092178 hasOpenAccess W2061092178 @default.
• W2061092178 hasPrimaryLocation W20610921781 @default.
• W2061092178 hasRelatedWork W1505805220 @default.
• W2061092178 hasRelatedWork W1507732063 @default.
• W2061092178 hasRelatedWork W1791436544 @default.
• W2061092178 hasRelatedWork W1985426543 @default.
• W2061092178 hasRelatedWork W2019529003 @default.
• W2061092178 hasRelatedWork W2083745007 @default.
• W2061092178 hasRelatedWork W2350596292 @default.
• W2061092178 hasRelatedWork W2392598031 @default.
• W2061092178 hasRelatedWork W2826646794 @default.
• W2061092178 hasRelatedWork W787804534 @default.
• W2061092178 hasVolume "182" @default.
• W2061092178 isParatext "false" @default.
• W2061092178 isRetracted "false" @default.
• W2061092178 magId "2061092178" @default.
• W2061092178 workType "article" @default.