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- W206109903 abstract "An effective innate response to microbial product requires the identification of pathogen-associated molecular patterns (PAMPs, e.g., dsRNA, CpGDNA or LPS), by the host via pattern recognition receptors (PRR; 1,2). Two different recognition systems were established to explain the activation of innate immunity by microbial product. The first PRR is intracellular and utilizes the PKR to recognize dsRNA, an intermediate product during viral replication (3). The second PRR is a cell surface receptor e.g., Toll-like receptors (TLRs) (2,4). TLRs have been reported to interact and to initiate innate response to a variety of microbial products TLR4-LPS, TLR2-peptidoglycan, TLR5-flagelline, and TLR9-ISS-ODN (2,4)." @default.
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- W206109903 date "2002-01-01" @default.
- W206109903 modified "2023-09-27" @default.
- W206109903 title "5 Activation of Innate Immunity by Microbial Nucleic Acids" @default.
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- W206109903 doi "https://doi.org/10.1007/978-1-59259-305-7_5" @default.
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