FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2061105384> ?p ?o ?g. }

• W2061105384 endingPage "92" @default.
• W2061105384 startingPage "83" @default.
• W2061105384 abstract "The fumarate and nitrate reduction (FNR) regulator is the master switch for the transition between anaerobic and aerobic respiration in Escherichia coli. Reaction of dimeric [4Fe-4S] FNR with O2 results in conversion of the cluster into a [2Fe-2S] form, via a [3Fe-4S] intermediate, leading to the loss of DNA binding through dissociation of the dimer into monomers. In the present paper, we report studies of two previously identified variants of FNR, D154A and I151A, in which the form of the cluster is decoupled from the association state. In vivo studies of permanently dimeric D154A FNR show that DNA binding does not affect the rate of cluster incorporation into the apoprotein or the rate of O2-mediated cluster loss. In vitro studies show that O2-mediated cluster conversion for D154A and the permanent monomer I151A FNR is the same as in wild-type FNR, but with altered kinetics. Decoupling leads to an increase in the rate of the [3Fe-4S]1+ into [2Fe-2S]2+ conversion step, consistent with the suggestion that this step drives association state changes in the wild-type protein. We have also shown that DNA-bound FNR reacts more rapidly with O2 than FNR free in solution, implying that transcriptionally active FNR is the preferred target for reaction with O2." @default.
• W2061105384 created "2016-06-24" @default.
• W2061105384 creator A5026718907 @default.
• W2061105384 creator A5042328891 @default.
• W2061105384 creator A5043337874 @default.
• W2061105384 creator A5050528640 @default.
• W2061105384 creator A5084275674 @default.
• W2061105384 date "2014-09-08" @default.
• W2061105384 modified "2023-10-06" @default.
• W2061105384 title "Influence of association state and DNA binding on the O2-reactivity of [4Fe-4S] fumarate and nitrate reduction (FNR) regulator" @default.
• W2061105384 cites W1589237644 @default.
• W2061105384 cites W1956224377 @default.
• W2061105384 cites W1968369852 @default.
• W2061105384 cites W1975421180 @default.
• W2061105384 cites W1983081312 @default.
• W2061105384 cites W2001569322 @default.
• W2061105384 cites W2007924134 @default.
• W2061105384 cites W2010907389 @default.
• W2061105384 cites W2022863863 @default.
• W2061105384 cites W2023949620 @default.
• W2061105384 cites W2025723285 @default.
• W2061105384 cites W2027864057 @default.
• W2061105384 cites W2032511325 @default.
• W2061105384 cites W2033298896 @default.
• W2061105384 cites W2033735656 @default.
• W2061105384 cites W2036985332 @default.
• W2061105384 cites W2037097058 @default.
• W2061105384 cites W2038704829 @default.
• W2061105384 cites W2070710045 @default.
• W2061105384 cites W2075040966 @default.
• W2061105384 cites W2076039091 @default.
• W2061105384 cites W2082000517 @default.
• W2061105384 cites W2082363762 @default.
• W2061105384 cites W2082964210 @default.
• W2061105384 cites W2091936669 @default.
• W2061105384 cites W2093522475 @default.
• W2061105384 cites W2109169041 @default.
• W2061105384 cites W2124896722 @default.
• W2061105384 cites W2129634655 @default.
• W2061105384 cites W2143018675 @default.
• W2061105384 cites W2146544655 @default.
• W2061105384 cites W2155094355 @default.
• W2061105384 cites W2169583771 @default.
• W2061105384 cites W217428907 @default.
• W2061105384 cites W80434006 @default.
• W2061105384 doi "https://doi.org/10.1042/bj20140169" @default.
• W2061105384 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4214427" @default.
• W2061105384 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25019503" @default.
• W2061105384 hasPublicationYear "2014" @default.
• W2061105384 type Work @default.
• W2061105384 sameAs 2061105384 @default.
• W2061105384 citedByCount "12" @default.
• W2061105384 countsByYear W20611053842016 @default.
• W2061105384 countsByYear W20611053842017 @default.
• W2061105384 countsByYear W20611053842018 @default.
• W2061105384 countsByYear W20611053842019 @default.
• W2061105384 countsByYear W20611053842020 @default.
• W2061105384 countsByYear W20611053842021 @default.
• W2061105384 countsByYear W20611053842022 @default.
• W2061105384 crossrefType "journal-article" @default.
• W2061105384 hasAuthorship W2061105384A5026718907 @default.
• W2061105384 hasAuthorship W2061105384A5042328891 @default.
• W2061105384 hasAuthorship W2061105384A5043337874 @default.
• W2061105384 hasAuthorship W2061105384A5050528640 @default.
• W2061105384 hasAuthorship W2061105384A5084275674 @default.
• W2061105384 hasBestOaLocation W20611053841 @default.
• W2061105384 hasConcept C102931765 @default.
• W2061105384 hasConcept C104317684 @default.
• W2061105384 hasConcept C121332964 @default.
• W2061105384 hasConcept C12554922 @default.
• W2061105384 hasConcept C148898269 @default.
• W2061105384 hasConcept C166940927 @default.
• W2061105384 hasConcept C178790620 @default.
• W2061105384 hasConcept C185592680 @default.
• W2061105384 hasConcept C2779546866 @default.
• W2061105384 hasConcept C521977710 @default.
• W2061105384 hasConcept C547475151 @default.
• W2061105384 hasConcept C552990157 @default.
• W2061105384 hasConcept C55493867 @default.
• W2061105384 hasConcept C62520636 @default.
• W2061105384 hasConcept C6929976 @default.
• W2061105384 hasConcept C71240020 @default.
• W2061105384 hasConcept C86803240 @default.
• W2061105384 hasConceptScore W2061105384C102931765 @default.
• W2061105384 hasConceptScore W2061105384C104317684 @default.
• W2061105384 hasConceptScore W2061105384C121332964 @default.
• W2061105384 hasConceptScore W2061105384C12554922 @default.
• W2061105384 hasConceptScore W2061105384C148898269 @default.
• W2061105384 hasConceptScore W2061105384C166940927 @default.
• W2061105384 hasConceptScore W2061105384C178790620 @default.
• W2061105384 hasConceptScore W2061105384C185592680 @default.
• W2061105384 hasConceptScore W2061105384C2779546866 @default.
• W2061105384 hasConceptScore W2061105384C521977710 @default.
• W2061105384 hasConceptScore W2061105384C547475151 @default.
• W2061105384 hasConceptScore W2061105384C552990157 @default.
• W2061105384 hasConceptScore W2061105384C55493867 @default.
• W2061105384 hasConceptScore W2061105384C62520636 @default.
• W2061105384 hasConceptScore W2061105384C6929976 @default.

• next