FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2061114145> ?p ?o ?g. }

• W2061114145 endingPage "22" @default.
• W2061114145 startingPage "15" @default.
• W2061114145 abstract "1 A pharmacological characterization was made of the effects of lysophosphatidyl-inositol (lysoPI) and -ethanolamine (lysoPE) on the Ca2+-sensitivity of contraction in α-toxin permeabilized rat mesenteric arteries. The effect of GTPγS (G-protein activator), diacylglycerols (DAGs, dioctanoyl glycerol (diC8) and 1-stearoyl-2-arachidonoyl-sn-glycerol) and phorbol myristate acetate (PMA, protein kinase C (PKC) activator) on Ca2+-sensitivity was also assessed. 2 LysoPI increased the Ca2+-sensitivity, demonstrated by both an increase in tension induced by 1 μm [Ca2+]free and an increase in the Ca2+-sensitivity of Ca2+ concentration-tension curves. LysoPE did not enhance force or Ca2+-sensitivity. 3 GTPγS enhanced force at constant Ca2+, increased the Ca2+-sensitivity, and increased force under Ca2+-free conditions. PMA also increased force at constant Ca2+ and increased Ca2+-sensitivity, but caused no force development under Ca2+-free conditions. 4 DAGs, both diC8 and the more physiological relevant DAG, 1-stearoyl-2-arachidonoyl-sn-glycerol, enhanced force at constant Ca2+ and increased the Ca2+-sensitivity. DiC8, in contrast to 1-stearoyl-2-arachidonoyl-sn-glycerol, caused force development under Ca2+-free conditions and substantially enhanced force at maximal Ca2+-induced contraction. GDP-β-S abolished the increased Ca2+-sensitization induced by noradrenaline, but not that by DAGs. 5 The PKC inhibitor calphostin C completely abolished Ca2+-sensitization induced by all of the Ca2+-sensitizing agents. 6 These results show that lysoPI can increase the Ca2+-sensitivity of smooth muscle contraction, and the Ca2+-sensitization induced by DAGs was not completely G-protein mediated, because it was not inhibited by GDP-β-S. A central role for PKC in regulation of Ca2+-sensitization in rat mesenteric small arteries was indicated by the abolishment of Ca2+-sensitization by calphostin C." @default.
• W2061114145 created "2016-06-24" @default.
• W2061114145 creator A5081134319 @default.
• W2061114145 date "1996-09-01" @default.
• W2061114145 modified "2023-09-29" @default.
• W2061114145 title "Calphostin C-sensitive enhancements of force by lysophosphatidylinositol and diacylglycerols in mesenteric arteries from the rat" @default.
• W2061114145 cites W125221118 @default.
• W2061114145 cites W1495958634 @default.
• W2061114145 cites W1507801782 @default.
• W2061114145 cites W1514066364 @default.
• W2061114145 cites W1542006519 @default.
• W2061114145 cites W1575679245 @default.
• W2061114145 cites W1586275583 @default.
• W2061114145 cites W1973226685 @default.
• W2061114145 cites W1999929858 @default.
• W2061114145 cites W2003268498 @default.
• W2061114145 cites W2003499757 @default.
• W2061114145 cites W2004017438 @default.
• W2061114145 cites W2040730664 @default.
• W2061114145 cites W2040870628 @default.
• W2061114145 cites W2042973128 @default.
• W2061114145 cites W2043036419 @default.
• W2061114145 cites W2067151239 @default.
• W2061114145 cites W2089553776 @default.
• W2061114145 cites W2089742414 @default.
• W2061114145 cites W2109451600 @default.
• W2061114145 cites W2160176046 @default.
• W2061114145 cites W2256927800 @default.
• W2061114145 cites W2279424556 @default.
• W2061114145 cites W2287215836 @default.
• W2061114145 cites W2309251585 @default.
• W2061114145 cites W2343759632 @default.
• W2061114145 cites W2409772950 @default.
• W2061114145 cites W2415958775 @default.
• W2061114145 cites W4211131955 @default.
• W2061114145 doi "https://doi.org/10.1111/j.1476-5381.1996.tb15671.x" @default.
• W2061114145 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1915738" @default.
• W2061114145 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8872351" @default.
• W2061114145 hasPublicationYear "1996" @default.
• W2061114145 type Work @default.
• W2061114145 sameAs 2061114145 @default.
• W2061114145 citedByCount "11" @default.
• W2061114145 countsByYear W20611141452012 @default.
• W2061114145 countsByYear W20611141452015 @default.
• W2061114145 countsByYear W20611141452020 @default.
• W2061114145 crossrefType "journal-article" @default.
• W2061114145 hasAuthorship W2061114145A5081134319 @default.
• W2061114145 hasBestOaLocation W20611141452 @default.
• W2061114145 hasConcept C11960822 @default.
• W2061114145 hasConcept C12554922 @default.
• W2061114145 hasConcept C126322002 @default.
• W2061114145 hasConcept C134018914 @default.
• W2061114145 hasConcept C163415756 @default.
• W2061114145 hasConcept C170493617 @default.
• W2061114145 hasConcept C181199279 @default.
• W2061114145 hasConcept C185592680 @default.
• W2061114145 hasConcept C195794163 @default.
• W2061114145 hasConcept C2776387844 @default.
• W2061114145 hasConcept C2776820930 @default.
• W2061114145 hasConcept C2779395532 @default.
• W2061114145 hasConcept C2780043322 @default.
• W2061114145 hasConcept C2780245509 @default.
• W2061114145 hasConcept C2780771799 @default.
• W2061114145 hasConcept C2992686903 @default.
• W2061114145 hasConcept C55493867 @default.
• W2061114145 hasConcept C71924100 @default.
• W2061114145 hasConcept C86803240 @default.
• W2061114145 hasConcept C88045685 @default.
• W2061114145 hasConceptScore W2061114145C11960822 @default.
• W2061114145 hasConceptScore W2061114145C12554922 @default.
• W2061114145 hasConceptScore W2061114145C126322002 @default.
• W2061114145 hasConceptScore W2061114145C134018914 @default.
• W2061114145 hasConceptScore W2061114145C163415756 @default.
• W2061114145 hasConceptScore W2061114145C170493617 @default.
• W2061114145 hasConceptScore W2061114145C181199279 @default.
• W2061114145 hasConceptScore W2061114145C185592680 @default.
• W2061114145 hasConceptScore W2061114145C195794163 @default.
• W2061114145 hasConceptScore W2061114145C2776387844 @default.
• W2061114145 hasConceptScore W2061114145C2776820930 @default.
• W2061114145 hasConceptScore W2061114145C2779395532 @default.
• W2061114145 hasConceptScore W2061114145C2780043322 @default.
• W2061114145 hasConceptScore W2061114145C2780245509 @default.
• W2061114145 hasConceptScore W2061114145C2780771799 @default.
• W2061114145 hasConceptScore W2061114145C2992686903 @default.
• W2061114145 hasConceptScore W2061114145C55493867 @default.
• W2061114145 hasConceptScore W2061114145C71924100 @default.
• W2061114145 hasConceptScore W2061114145C86803240 @default.
• W2061114145 hasConceptScore W2061114145C88045685 @default.
• W2061114145 hasIssue "1" @default.
• W2061114145 hasLocation W20611141451 @default.
• W2061114145 hasLocation W20611141452 @default.
• W2061114145 hasLocation W20611141453 @default.
• W2061114145 hasLocation W20611141454 @default.
• W2061114145 hasOpenAccess W2061114145 @default.
• W2061114145 hasPrimaryLocation W20611141451 @default.
• W2061114145 hasRelatedWork W1986430910 @default.
• W2061114145 hasRelatedWork W2000923181 @default.
• W2061114145 hasRelatedWork W2043794976 @default.

• next