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• W2061133807 abstract "Adenomatous polyps (AP) of the gastrointestinal tract in children are very rare. Because of their potential malignancy, they are of great clinical importance. There is little experience in the management of children with AP. The immunohistochemical expression of the Lewis blood group antigens (BGA) (sialosyl-Lea, Lea, Leb, Lex, and Ley) and the number of activated nucleoli with the silver staining method for nucleolar organizer regions (AgNORs) were studied in two children with AP. In a girl with isolated AP of the stomach and colon, it was found that antigens Leb and s-Lea were expressed extensively in the gastric adenoma, and sialosyl-Lea throughout the entire length of the rectal adenoma crypts, but in the AgNORs stain the number of nucleoli ranged from two to four, evidencing changes of a benign character. In the case of familial adenomatous polyposis diagnosed in a 9-year-old boy, in some colonic adenomas the number of activated nucleoli was greater than five, and the Leb antigen was expressed in superficial epithelial cells in one of the adenomas. Also, extensive expression of antigens Ley and s-Lea throughout the entire length of the crypt in another polyp removed was observed. We believe that immunohistochemical study of the intensity and extent of the expression of Lewis BGA in the polyp tissue simultaneously with the determination of the number of activated nucleoli by the AgNORs staining method can be helpful in better analysis of cytological risk factors of a malignant transformation." @default.
• W2061133807 created "2016-06-24" @default.
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• W2061133807 date "2000-06-01" @default.
• W2061133807 modified "2023-09-27" @default.
• W2061133807 title "Lewis Antigens and Argyrophilic Nucleolar Organizer Regions Staining for Assessment of Potential Malignancy of Adenomatous Polyps of the Gastrointestinal Tract in Children" @default.
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• W2061133807 doi "https://doi.org/10.1089/02724570050109675" @default.
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