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- W2061134498 abstract "Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CAAbl kinases are a family of non-receptor tyrosine kinases consisting of two members, Abl1 and Abl2 (Arg). In recent years, accumulating data support a role of Abl kinases in breast cancer that harbor enhanced expression and/or activation of these kinases. The Cancer Genome Atlas has recently reported that Abl2 is among the most highly amplified genes and overexpression of Abl2 correlates with poor survival in invasive breast cancer. In addition, Abl kinases are activated downstream of receptor tyrosine kinases, chemokine receptors and src family kinases, all of which are deregulated in breast cancer and drive tumor proliferation and invasion. In this study, we have uncovered a critical role of Abl kinases in the regulation of breast cancer metastasis to the bone. We found that the incidence of bone metastasis is significantly greater in breast cancer patients with high Abl expression. Using global transcriptome analysis (RNAseq) of breast cancer cells we uncovered a novel role for Abl kinases in regulating the expression of multiple pro-bone metastasis genes. Furthermore, both pharmacological inhibition and RNA interference mediated knockdown of Abl kinases resulted in markedly decreased osteolytic metastasis in vivo and decreased osteoclast activation in vitro. Together these findings support a role for Abl kinases in promoting osteolytic metastasis and suggest that Abl dependent signaling may be targeted to inhibit this process.Citation Format: Jun Wang. The role of Abl kinases in breast cancer bone metastasis. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 140. doi:10.1158/1538-7445.AM2014-140" @default.
- W2061134498 created "2016-06-24" @default.
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- W2061134498 date "2014-09-30" @default.
- W2061134498 modified "2023-09-27" @default.
- W2061134498 title "Abstract 140: The role of Abl kinases in breast cancer bone metastasis" @default.
- W2061134498 doi "https://doi.org/10.1158/1538-7445.am2014-140" @default.
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