FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2061135331> ?p ?o ?g. }

• W2061135331 endingPage "313" @default.
• W2061135331 startingPage "307" @default.
• W2061135331 abstract "Growing evidence suggests that reactive oxygen species such as hydrogen peroxide (H 2 O 2 ) can function as important signaling molecules in vascular cells. H 2 O 2 ‐activated redox‐sensitive pathways mediate both physiological and pathological responses given the location and concentration of H 2 O 2 . We showed previously for the first time that calcium/calmodulin‐dependent protein kinase II (CaMKII) is redox‐sensitive in endothelial cells, mediating H 2 O 2 upregulation of endothelial nitric oxide synthase. This response is always accompanied by an elongation phenotype of endothelial cells, implying modulation of actin cytoskeleton. In the present study, we investigated the role of CaMKII in H 2 O 2 activation of p38 MAPK/heat shock protein 27 (HSP27) pathway and ERK1/2, both of which have been known to regulate actin reorganization in endothelial cells. Addition of H 2 O 2 to bovine aortic endothelial cells increased ERK1/2 phosphorylation and activity, which was attenuated by a specific inhibitor of CaMKII, KN93. KN93 also prevented H 2 O 2 activation of p38 MAPK. Transfection of endothelial cells with a CaMKII‐specific inhibitory peptide (AA 281–309) reduced H 2 O 2 phosphorylation of p38 MAPK and ERK1/2. Furthermore, blockade of CaMKII or janus kinase 2 (JAK2, downstream of CaMKII) prevented H 2 O 2 activation of HSP27. KN93 attenuated, whereas AG490 (JAK2 inhibitor) abolished, H 2 O 2 ‐induced formation of actin stress fibers. Blockade of ERK1/2 inhibited H 2 O 2 phosphorylation of HSP27 transiently. It also partially prevented H 2 O 2 induction of actin stress fibers. In summary, redox‐sensitive activation of p38 MAPK/HSP27 pathway or ERK1/2 in endothelial cells requires CaMKII. These pathways are at least partially responsible for H 2 O 2 induced reorganization of actin cytoskeleton." @default.
• W2061135331 created "2016-06-24" @default.
• W2061135331 creator A5018191047 @default.
• W2061135331 creator A5031620134 @default.
• W2061135331 creator A5089433097 @default.
• W2061135331 date "2004-07-06" @default.
• W2061135331 modified "2023-10-14" @default.
• W2061135331 title "Role of CaMKII in hydrogen peroxide activation of ERK1/2, p38 MAPK, HSP27 and actin reorganization in endothelial cells" @default.
• W2061135331 cites W1530591884 @default.
• W2061135331 cites W1574937508 @default.
• W2061135331 cites W1859832010 @default.
• W2061135331 cites W1965571070 @default.
• W2061135331 cites W1983688371 @default.
• W2061135331 cites W1994155349 @default.
• W2061135331 cites W1998478526 @default.
• W2061135331 cites W2000155150 @default.
• W2061135331 cites W2009034887 @default.
• W2061135331 cites W2022224180 @default.
• W2061135331 cites W2023312698 @default.
• W2061135331 cites W2023900392 @default.
• W2061135331 cites W2035880579 @default.
• W2061135331 cites W2040801242 @default.
• W2061135331 cites W2041578282 @default.
• W2061135331 cites W2058392358 @default.
• W2061135331 cites W2063971300 @default.
• W2061135331 cites W2086089999 @default.
• W2061135331 cites W2088001417 @default.
• W2061135331 cites W2097642975 @default.
• W2061135331 cites W2104034706 @default.
• W2061135331 cites W2104068579 @default.
• W2061135331 cites W2107635756 @default.
• W2061135331 cites W2110361956 @default.
• W2061135331 cites W2122578071 @default.
• W2061135331 cites W2125278725 @default.
• W2061135331 cites W2128046825 @default.
• W2061135331 cites W2132734354 @default.
• W2061135331 cites W2135297555 @default.
• W2061135331 cites W2137199906 @default.
• W2061135331 cites W2139060480 @default.
• W2061135331 cites W2147902097 @default.
• W2061135331 cites W2148637873 @default.
• W2061135331 cites W2169878907 @default.
• W2061135331 doi "https://doi.org/10.1016/j.febslet.2004.06.061" @default.
• W2061135331 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15304367" @default.
• W2061135331 hasPublicationYear "2004" @default.
• W2061135331 type Work @default.
• W2061135331 sameAs 2061135331 @default.
• W2061135331 citedByCount "96" @default.
• W2061135331 countsByYear W20611353312012 @default.
• W2061135331 countsByYear W20611353312013 @default.
• W2061135331 countsByYear W20611353312014 @default.
• W2061135331 countsByYear W20611353312015 @default.
• W2061135331 countsByYear W20611353312016 @default.
• W2061135331 countsByYear W20611353312017 @default.
• W2061135331 countsByYear W20611353312018 @default.
• W2061135331 countsByYear W20611353312019 @default.
• W2061135331 countsByYear W20611353312020 @default.
• W2061135331 countsByYear W20611353312021 @default.
• W2061135331 countsByYear W20611353312022 @default.
• W2061135331 crossrefType "journal-article" @default.
• W2061135331 hasAuthorship W2061135331A5018191047 @default.
• W2061135331 hasAuthorship W2061135331A5031620134 @default.
• W2061135331 hasAuthorship W2061135331A5089433097 @default.
• W2061135331 hasConcept C104317684 @default.
• W2061135331 hasConcept C11960822 @default.
• W2061135331 hasConcept C184235292 @default.
• W2061135331 hasConcept C185592680 @default.
• W2061135331 hasConcept C205260736 @default.
• W2061135331 hasConcept C2779559962 @default.
• W2061135331 hasConcept C51551487 @default.
• W2061135331 hasConcept C55493867 @default.
• W2061135331 hasConcept C57074206 @default.
• W2061135331 hasConcept C68991219 @default.
• W2061135331 hasConcept C86803240 @default.
• W2061135331 hasConcept C95444343 @default.
• W2061135331 hasConcept C97029542 @default.
• W2061135331 hasConceptScore W2061135331C104317684 @default.
• W2061135331 hasConceptScore W2061135331C11960822 @default.
• W2061135331 hasConceptScore W2061135331C184235292 @default.
• W2061135331 hasConceptScore W2061135331C185592680 @default.
• W2061135331 hasConceptScore W2061135331C205260736 @default.
• W2061135331 hasConceptScore W2061135331C2779559962 @default.
• W2061135331 hasConceptScore W2061135331C51551487 @default.
• W2061135331 hasConceptScore W2061135331C55493867 @default.
• W2061135331 hasConceptScore W2061135331C57074206 @default.
• W2061135331 hasConceptScore W2061135331C68991219 @default.
• W2061135331 hasConceptScore W2061135331C86803240 @default.
• W2061135331 hasConceptScore W2061135331C95444343 @default.
• W2061135331 hasConceptScore W2061135331C97029542 @default.
• W2061135331 hasIssue "1-3" @default.
• W2061135331 hasLocation W20611353311 @default.
• W2061135331 hasLocation W20611353312 @default.
• W2061135331 hasOpenAccess W2061135331 @default.
• W2061135331 hasPrimaryLocation W20611353311 @default.
• W2061135331 hasRelatedWork W146043819 @default.
• W2061135331 hasRelatedWork W1964224666 @default.
• W2061135331 hasRelatedWork W2034689332 @default.
• W2061135331 hasRelatedWork W2074332495 @default.

• next