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• W2061140737 abstract "BackgroundUrinary mercury (U-Hg) excretion is a commonly used biomarker for mercury exposure from dental amalgam restorations.ObjectivesOur goal was to determine the most efficient measure of dental amalgam exposure for use in analyses concerning U-Hg in children.MethodsWe analyzed time-sensitive longitudinal amalgam exposure data in children randomized to amalgam restorations (n = 267) during the 5-year New England Children’s Amalgam Trial. We calculated 8 measures of amalgam, evaluating current versus cumulative exposure, teeth versus surfaces, and total versus posterior occlusal amalgams. Urine samples collected during follow-up years 3–5 were analyzed for mercury excretion. Multivariate models for current and cumulative U-Hg excretion estimated associations between exposures and U-Hg.ResultsAt the end of follow-up, the average (± SD) cumulative exposure was 10.3 ± 6.1 surfaces and 5.7 ± 2.9 teeth ever filled with amalgam, corresponding to 30 ± 21 surface-years. Amalgam measures and U-Hg were moderately correlated. Of amalgam exposure measures, the current total of amalgam surfaces was the most robust predictor of current U-Hg, whereas posterior occlusal surface-years was best for cumulative U-Hg. In multivariate models, each additional amalgam surface present was associated with a 9% increase in current U-Hg, and each additional posterior occlusal surface-year was associated with a 3% increase in cumulative U-Hg excretion (p < 0.001).ConclusionsOne single measure of amalgam exposure is insufficient. Studies of cumulative effects of mercury from amalgam exposure in children are likely to have improved validity and precision if time-sensitive amalgam exposure measures are used. In contrast, simple counts of current amalgam fillings are adequate to capture amalgam-related current U-Hg." @default.
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• W2061140737 date "2008-02-01" @default.
• W2061140737 modified "2023-09-29" @default.
• W2061140737 title "Dental Amalgam Exposure and Urinary Mercury Levels in Children: The New England Children’s Amalgam Trial" @default.
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• W2061140737 doi "https://doi.org/10.1289/ehp.10440" @default.
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