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- W2061146307 abstract "Recently we found that KMnO4 oxidation of DNA oligomers containing a 7,8-dihydro-8-oxoguanine (8-oxo-G) residue induces damage to the neighboring base residues; other modified bases, 7,8-dihydro-8-oxoadenine (8-oxo-A) and 5-hydroxyuracil (5-oh-U), show similar behavior in DNA. The present study indicated that the ability to induce damage, which could also occur by the oxidation of a 5-oh-C residue, was low as in the case of 5-oh-U. On the other hand, in order to examine the pathways and the intermediates for the oxidative degradation of 8-oxo-A, we have carried out the KMnO4 oxidation using an 8-oxo-2'-deoxyadenosine derivative as a model and have determined the structures of the three major products." @default.
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- W2061146307 date "1999-11-01" @default.
- W2061146307 modified "2023-09-26" @default.
- W2061146307 title "Further studies of KMnO4 oxidation of synthetic DNAs containing oxidatively damaged bases" @default.
- W2061146307 doi "https://doi.org/10.1093/nass/42.1.35" @default.
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