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• W2061147117 abstract "Drugs of abuse, such as amphetamine and morphine, produce reward-related shifts on intracranial self-stimulation (ICSS) thresholds. The facilitatory effects on ICSS thresholds of drugs that act through the GABAergic system, however, are reported to be attributed to their antiseizure and anticonvulsant effects, rather than their reinforcing effects. Using a rate–frequency ICSS paradigm, we examined the effects of amphetamine (a reinforcing drug of abuse that acts via the catecholaminergic system), pentobarbital (a GABAA receptor agonist and reinforcing barbiturate with anticonvulsant properties), and gabapentin (a nonspecific GABAergic agonist and anticonvulsant with low abuse potential) on ICSS M50 indices. All three doses of amphetamine (0.5, 1.0, and 2.0 mg/kg) and pentobarbital (2.5, 5.0, and 10.0 mg/kg) significantly lowered rate–frequency M50 values. Gabapentin, on the other hand, significantly raised rate–frequency M50 values, albeit only at the highest dose administered (30 mg/kg). Our results indicate that shifts in ICSS M50 values produced by pentobarbital are associated with the reinforcing, not the anticonvulsant, effect of pentobarbital. These results are consistent with the view that there is a common system underlying the reinforcing effects of drugs and ICSS reinforcement, and suggest that the reinforcing and anticonvulsant effects of GABA agonists are dissociable." @default.
• W2061147117 created "2016-06-24" @default.
• W2061147117 creator A5006575192 @default.
• W2061147117 creator A5083352323 @default.
• W2061147117 date "2003-09-01" @default.
• W2061147117 modified "2023-09-25" @default.
• W2061147117 title "Reinforcing versus anticonvulsant drugs: effects on intracranial self-stimulation rate–frequency M50 indices" @default.
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• W2061147117 doi "https://doi.org/10.1016/s0166-4328(03)00110-4" @default.
• W2061147117 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12946613" @default.
• W2061147117 hasPublicationYear "2003" @default.
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