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- W2061148091 abstract "We investigated the regulation of the expression of two members of the C/EBP family of transcriptional activators, C/EBPα and C/EBPβ, in brown adipose tissue in mice. Less than one hour of cold exposure led to dramatic changes in the expression of both genes. C/EBPα steady‐state mRNA and protein levels were drastically and rapidly reduced whereas C/EBPβ mRNA and protein levels were induced severalfold. Also norepinephrine injection affected the expression of the transcription factors. Preconfluent cells in brown fat primary cultures responded to norepinephrine with a decrease in C/EBPα and an increase in C/EBPβ mRNA; in confluent cells the expression of both factors was increased. Thus, C/EBPα and C/EBPβ gene expression is under adrenergic control both in vivo and in vitro but the type of response is directed by the degree of differentiation of the cells." @default.
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- W2061148091 date "1993-03-08" @default.
- W2061148091 modified "2023-09-30" @default.
- W2061148091 title "Differential adrenergic regulation of C/EBPα and C/EBPβ in brown adipose tissue" @default.
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- W2061148091 doi "https://doi.org/10.1016/0014-5793(93)80519-z" @default.
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