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- W2061151497 abstract "RATIONALE: Stevens-Johnson Syndrome (SJS) is an immunologic inflammatory disease characterized by severe mucocutaneous eruption. It is most commonly caused by medication or infection. Morbidity and mortality may be significant. Although there is no universally accepted treatment of SJS, systemic corticosteroids and intravenous immune globulin (IVIG) are frequently utilized as treatment modalities. However, prompt SJS diagnosis is required, as these medications are most effective when started early. We sought to determine the current diagnostic timeline for SJS in children. METHODS: Medical records for pediatric patients admitted to the hospital with a primary ICD9 code of 695.1 were retrospectively reviewed. Patients were included in our analysis if they met clinical criteria for SJS (vesicobullous rash + ≥2 mucous membranes involved). RESULTS: Ten patients met criteria for SJS. An identifiable cause was found in 6 patients (one from infection; 5 drug-related), a possible cause in 2 patients, and 2 others had SJS due to unknown causes. Mean duration of illness prior to diagnosis was 7.2 ± 5.5 days. However, mean time to diagnosis was shorter for patients evaluated by Allergy/Immunology (A/I) (4.5 ± 1.4 days) than those patients evaluated by Dermatology (6 ± 3.2 days) or Infectious Disease (11.5 ± 6.9 days). Eight of 10 SJS patients received systemic corticosteroids (mean time to treatment =2.8 ± 2.0 days) and no patients received IVIG. CONCLUSIONS: A/I consultation may result in more prompt SJS diagnosis, enabling prompt initiation of therapies such as systemic corticosteroids or IVIG." @default.
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- W2061151497 date "2007-01-01" @default.
- W2061151497 modified "2023-09-27" @default.
- W2061151497 title "Prompt Recognition And Timely Diagnosis Of Stevens-Johnson Syndrome" @default.
- W2061151497 doi "https://doi.org/10.1016/j.jaci.2006.12.435" @default.
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