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• W2061152008 abstract "No AccessJournal of UrologyInvestigative Urology1 Feb 2012Multiphoton Imaging and Laser Ablation of Rodent Spermatic Cord Nerves: Potential Treatment for Patients With Chronic Orchialgia Ranjith Ramasamy, Joshua Sterling, Philip S. Li, Brian D. Robinson, Sijo Parekattil, Jie Chen, Diane Felsen, Sushmita Mukherjee, Marc Goldstein, and Peter N. Schlegel Ranjith RamasamyRanjith Ramasamy Department of Urology, Weill Cornell Medical College, New York, New York More articles by this author , Joshua SterlingJoshua Sterling Department of Biochemistry, Weill Cornell Medical College, New York, New York More articles by this author , Philip S. LiPhilip S. Li Department of Urology, Weill Cornell Medical College, New York, New York More articles by this author , Brian D. RobinsonBrian D. Robinson Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, New York More articles by this author , Sijo ParekattilSijo Parekattil Department of Urology, Winter Haven Hospital, University of Florida, Winter Haven, Florida More articles by this author , Jie ChenJie Chen Department of Urology, Weill Cornell Medical College, New York, New York More articles by this author , Diane FelsenDiane Felsen Department of Urology, Weill Cornell Medical College, New York, New York More articles by this author , Sushmita MukherjeeSushmita Mukherjee Department of Biochemistry, Weill Cornell Medical College, New York, New York More articles by this author , Marc GoldsteinMarc Goldstein Department of Urology, Weill Cornell Medical College, New York, New York More articles by this author , and Peter N. SchlegelPeter N. Schlegel Department of Urology, Weill Cornell Medical College, New York, New York More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2011.09.143AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: Microsurgical denervation of the spermatic cord has been done to treat chronic orchialgia. However, identifying the site of spermatic cord nerves is not feasible with an operating microscope or robotic stereoscope. We used multiphoton microscopy, a novel laser imaging technology, to identify and selectively ablate spermatic cord nerves in the rat. Materials and Methods: The spermatic cords of adult male Sprague-Dawley® rats were initially imaged in vivo under a low power multiphoton microscopy laser. After assessing the number, diameter and site (vasal vs perivasal) of the nerves a higher power laser using the same objective was used to ablate the nerves. The precision of nerve ablation and the preservation of surrounding structures were determined by histological analysis. We assessed the heterogeneity of the number of nerves with the Wilcoxon signed rank test. Results: The average number of nerves per spermatic cord was 10, which was similar bilaterally (p = 0.13). The vas and perivasal structures had a similar number of nerves (p = 0.4). The median diameter of all nerves was 32 μm. Confirmation of nerve ablation, and preservation of the vas deferens and vasculature were anatomically validated by histological analysis. Conclusions: Multiphoton microscopy can identify and ablate nerves selectively in vivo in the rat. It can potentially be used for spermatic cord denervation to treat chronic orchialgia. Such imaging may increase the efficacy of nerve ablation and can avoid the potential risks of testicular atrophy and hydrocele associated with spermatic cord microsurgical denervation. 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Google Scholar 15 : Behavioral and urological evaluation of a testicular pain model. Urology2010; 75: 943. Google Scholar © 2012 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited ByParekattil S, Gudeloglu A, Brahmbhatt J, Priola K, Vieweg J and Allan R (2018) Trifecta Nerve Complex: Potential Anatomical Basis for Microsurgical Denervation of the Spermatic Cord for Chronic OrchialgiaJournal of Urology, VOL. 190, NO. 1, (265-270), Online publication date: 1-Jul-2013.Najari B, Ramasamy R, Sterling J, Aggarwal A, Sheth S, Li P, Dubin J, Goldenberg S, Jain M, Robinson B, Shevchuk M, Scherr D, Goldstein M, Mukherjee S and Schlegel P (2018) Pilot Study of the Correlation of Multiphoton Tomography of Ex Vivo Human Testis with HistologyJournal of Urology, VOL. 188, NO. 2, (538-543), Online publication date: 1-Aug-2012. Volume 187Issue 2February 2012Page: 733-738 Advertisement Copyright & Permissions© 2012 by American Urological Association Education and Research, Inc.Keywordsspermatic cordpaintestismultiphotonfluorescencemicroscopydenervationMetricsAuthor Information Ranjith Ramasamy Department of Urology, Weill Cornell Medical College, New York, New York More articles by this author Joshua Sterling Department of Biochemistry, Weill Cornell Medical College, New York, New York More articles by this author Philip S. Li Department of Urology, Weill Cornell Medical College, New York, New York More articles by this author Brian D. Robinson Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, New York More articles by this author Sijo Parekattil Department of Urology, Winter Haven Hospital, University of Florida, Winter Haven, Florida More articles by this author Jie Chen Department of Urology, Weill Cornell Medical College, New York, New York More articles by this author Diane Felsen Department of Urology, Weill Cornell Medical College, New York, New York More articles by this author Sushmita Mukherjee Department of Biochemistry, Weill Cornell Medical College, New York, New York More articles by this author Marc Goldstein Department of Urology, Weill Cornell Medical College, New York, New York More articles by this author Peter N. Schlegel Department of Urology, Weill Cornell Medical College, New York, New York More articles by this author Expand All Advertisement PDF DownloadLoading ..." @default.
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