FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2061155431> ?p ?o ?g. }

• W2061155431 endingPage "105" @default.
• W2061155431 startingPage "97" @default.
• W2061155431 abstract "The non-sedating anti-allergic drug astemizole, apart from its potential to antagonise H1 receptors, inhibits the release of inflammation mediators from mast cells. To study the mechanism of this inhibition, we investigated the effects of astemizole and one of its active metabolites, norastemizole, on different phases of FcεRI (the high affinity receptor for the immunoglobulin IgE) receptor-activated signal transduction in rat basophilic leukemia cells (RBL-2H3), leading to exocytosis. Cells were stimulated either through antigen, or thapsigargin, or synergistic combinations of FcεRI receptor activation with either adenosine A3 receptors or integrins, activated by fibronectin adherence. The effects of the drugs on mediator release, inositol 1,4,5-trisphosphate formation, tyrosine phosphorylation of cellular proteins and Ca2+ fluxes were investigated. Inositol 1,4,5-trisphosphate levels are not affected. Astemizole increased tyrosine phosphorylation in resting cells, especially a 96-kDa protein band. Particularly tyrosine phosphorylation related to post Ca2+ processes is changed after cell triggering in the presence of astemizole. Both drugs inhibit the influx of 45Ca2+, with similar dose response curves as for the inhibition of exocytosis. Astemizole but not norastemizole, when used in resting cells, released Ca2+ from intracellular stores. Astemizole (>15 μM) also induced exocytosis in resting cells. It did not induce additional changes in its inhibiting effect when cells were triggered with synergistic combinations of FcεRI receptor activation with either adenosine A3 receptors or integrins. Effects on haemolysis of erythrocytes and differential scanning calorimetry in liposomes showed clear differences in membrane perturbation between astemizole and norastemizole. The observed differences, and the role of membrane perturbation in the action on Ca2+ fluxes, are discussed. © 1997 Elsevier Science B.V. All rights reserved." @default.
• W2061155431 created "2016-06-24" @default.
• W2061155431 creator A5019311190 @default.
• W2061155431 creator A5026656759 @default.
• W2061155431 creator A5048362835 @default.
• W2061155431 creator A5067323648 @default.
• W2061155431 creator A5069941279 @default.
• W2061155431 creator A5083635823 @default.
• W2061155431 date "1997-03-01" @default.
• W2061155431 modified "2023-09-26" @default.
• W2061155431 title "Effects of the anti-allergics astemizole and norastemizole on FcεRI receptor-mediated signal transduction processes" @default.
• W2061155431 cites W1451010299 @default.
• W2061155431 cites W1505084152 @default.
• W2061155431 cites W1543778012 @default.
• W2061155431 cites W1545295983 @default.
• W2061155431 cites W1557763992 @default.
• W2061155431 cites W1599965186 @default.
• W2061155431 cites W1604722617 @default.
• W2061155431 cites W1874327812 @default.
• W2061155431 cites W1944197208 @default.
• W2061155431 cites W1960680499 @default.
• W2061155431 cites W1975376834 @default.
• W2061155431 cites W1979611729 @default.
• W2061155431 cites W1982892532 @default.
• W2061155431 cites W1985028121 @default.
• W2061155431 cites W1992967207 @default.
• W2061155431 cites W2016080457 @default.
• W2061155431 cites W2024077540 @default.
• W2061155431 cites W2031928878 @default.
• W2061155431 cites W2033606609 @default.
• W2061155431 cites W2044784133 @default.
• W2061155431 cites W2053643150 @default.
• W2061155431 cites W2057887597 @default.
• W2061155431 cites W2058074251 @default.
• W2061155431 cites W2063535351 @default.
• W2061155431 cites W2075839348 @default.
• W2061155431 cites W2081096724 @default.
• W2061155431 cites W2082379544 @default.
• W2061155431 cites W2096437759 @default.
• W2061155431 cites W2111696845 @default.
• W2061155431 cites W2138885497 @default.
• W2061155431 cites W2197989280 @default.
• W2061155431 cites W2237551810 @default.
• W2061155431 cites W4247297155 @default.
• W2061155431 doi "https://doi.org/10.1016/s0014-2999(96)00981-8" @default.
• W2061155431 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9088877" @default.
• W2061155431 hasPublicationYear "1997" @default.
• W2061155431 type Work @default.
• W2061155431 sameAs 2061155431 @default.
• W2061155431 citedByCount "13" @default.
• W2061155431 countsByYear W20611554312012 @default.
• W2061155431 countsByYear W20611554312017 @default.
• W2061155431 crossrefType "journal-article" @default.
• W2061155431 hasAuthorship W2061155431A5019311190 @default.
• W2061155431 hasAuthorship W2061155431A5026656759 @default.
• W2061155431 hasAuthorship W2061155431A5048362835 @default.
• W2061155431 hasAuthorship W2061155431A5067323648 @default.
• W2061155431 hasAuthorship W2061155431A5069941279 @default.
• W2061155431 hasAuthorship W2061155431A5083635823 @default.
• W2061155431 hasConcept C1122143 @default.
• W2061155431 hasConcept C134018914 @default.
• W2061155431 hasConcept C170493617 @default.
• W2061155431 hasConcept C185592680 @default.
• W2061155431 hasConcept C2776129107 @default.
• W2061155431 hasConcept C2777146706 @default.
• W2061155431 hasConcept C2777553839 @default.
• W2061155431 hasConcept C49802076 @default.
• W2061155431 hasConcept C55493867 @default.
• W2061155431 hasConcept C62478195 @default.
• W2061155431 hasConcept C79879829 @default.
• W2061155431 hasConcept C86803240 @default.
• W2061155431 hasConcept C95444343 @default.
• W2061155431 hasConcept C98274493 @default.
• W2061155431 hasConceptScore W2061155431C1122143 @default.
• W2061155431 hasConceptScore W2061155431C134018914 @default.
• W2061155431 hasConceptScore W2061155431C170493617 @default.
• W2061155431 hasConceptScore W2061155431C185592680 @default.
• W2061155431 hasConceptScore W2061155431C2776129107 @default.
• W2061155431 hasConceptScore W2061155431C2777146706 @default.
• W2061155431 hasConceptScore W2061155431C2777553839 @default.
• W2061155431 hasConceptScore W2061155431C49802076 @default.
• W2061155431 hasConceptScore W2061155431C55493867 @default.
• W2061155431 hasConceptScore W2061155431C62478195 @default.
• W2061155431 hasConceptScore W2061155431C79879829 @default.
• W2061155431 hasConceptScore W2061155431C86803240 @default.
• W2061155431 hasConceptScore W2061155431C95444343 @default.
• W2061155431 hasConceptScore W2061155431C98274493 @default.
• W2061155431 hasIssue "1" @default.
• W2061155431 hasLocation W20611554311 @default.
• W2061155431 hasLocation W20611554312 @default.
• W2061155431 hasOpenAccess W2061155431 @default.
• W2061155431 hasPrimaryLocation W20611554311 @default.
• W2061155431 hasRelatedWork W1987061958 @default.
• W2061155431 hasRelatedWork W2012378759 @default.
• W2061155431 hasRelatedWork W2052792723 @default.
• W2061155431 hasRelatedWork W2061155431 @default.
• W2061155431 hasRelatedWork W2062399962 @default.
• W2061155431 hasRelatedWork W2122679884 @default.

• next