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- W2061165629 abstract "A number of two-compartment models have been developed for the analysis of arterial spin labeling (ASL) data, from which both cerebral blood flow (CBF) and capillary permeability-surface product (PS) can be estimated. To derive values of PS, the volume fraction of the ASL signal arising from the intravascular space (v(bw)) must be known a priori. We examined the use of diffusion-weighted imaging (DWI) and subsequent analysis using the intravoxel incoherent motion model to determine v(bw) in the human brain. These data were then used in a two-compartment ASL model to estimate PS. Imaging was performed in 10 healthy adult subjects, and repeated in five subjects to test reproducibility. In gray matter (excluding large arteries), mean voxel-wise v(bw) was 2.3±0.2 mL blood/100 g tissue (all subjects mean±s.d.), and CBF and PS were 44±5 and 108±2 mL per 100 g per minute, respectively. After spatial smoothing using a 6-mm full width at half maximum Gaussian kernel, the coefficient of repeatability of CBF, v(bw) and PS were 8 mL per 100 g per minute, 0.4 mL blood/100 g tissue, and 13 mL per 100 g per minute, respectively. Our results show that the combined use of ASL and DWI can provide a new, noninvasive methodology for estimating v(bw) and PS directly, with reproducibility that is sufficient for clinical use." @default.
- W2061165629 created "2016-06-24" @default.
- W2061165629 creator A5010443169 @default.
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- W2061165629 date "2012-09-19" @default.
- W2061165629 modified "2023-10-11" @default.
- W2061165629 title "Combined Arterial Spin Labeling and Diffusion-Weighted Imaging for Noninvasive Estimation of Capillary Volume Fraction and Permeability-Surface Product in the Human Brain" @default.
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- W2061165629 doi "https://doi.org/10.1038/jcbfm.2012.125" @default.
- W2061165629 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3597361" @default.
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