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- W2061173800 abstract "A newly isolated interferon-gamma (IFN-gamma) immunoreactive molecule, neuronal IFN-gamma, and recombinant lymphocyte-derived IFN-gamma were injected intracerebroventricularly (i.c.v.) through a previously implanted cannula into adult male rats during both the light and the dark phases of the light/dark cycle. The two molecules caused a reduction in both frequency and duration of rearing and locomotion during the dark, but not the light, phase. A molecule isolated from Trypanosoma brucei brucei, a parasite of the same subspecies of trypanosomes which causes African sleeping sickness, can induce production and release of IFN-gamma and neuronal IFN-gamma from lymphocytes and neurons, respectively. I.c.v. injection of this factor also reduced rearing during the dark period, but to a less extent. Thus, neuronal IFN-gamma appears to have effects on animal behaviour in common with lymphocyte-derived IFN-gamma. This study highlights the potential role of these cytokines in behaviour disturbances." @default.
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- W2061173800 date "1994-06-01" @default.
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- W2061173800 title "Interferon-γ and a factor derived from trypanosomes cause behavioural changes in the rat" @default.
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- W2061173800 doi "https://doi.org/10.1016/0166-4328(94)90025-6" @default.
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