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• W2061176839 abstract "Andrographolide (Andro) has been reported to have anticancer activity in multiple types of cancer due to its capacity to inactivate NF- κ B pathway. Previous studies showed the therapeutic potential of targeting NF- κ B pathway in nasopharyngeal carcinoma (NPC). However, the anticancer activity of Andro in NPC has not been reported. In this study, we defined the anticancer effects of Andro in NPC and elucidated its potential mechanisms of action. Our results showed that Andro significantly inhibited the proliferation and invasion of NPC cells (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M2><mml:mi>P</mml:mi><mml:mo><</mml:mo><mml:mn>0.05</mml:mn></mml:math>, resp.). These anticancer activities were associated with cell apoptosis, cell death and induction of cell cycle arrest, and the downregulation of NF- κ B target genes. This work provides evidence that NF- κ B pathway is a potential therapeutic target and may also be indispensable in the Andro-mediated anticancer activities in nasopharyngeal carcinoma." @default.
• W2061176839 created "2016-06-24" @default.
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• W2061176839 date "2015-01-01" @default.
• W2061176839 modified "2023-09-26" @default.
• W2061176839 title "Andrographolide Suppresses Proliferation of Nasopharyngeal Carcinoma Cells via Attenuating NF-<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M1><mml:mrow><mml:mi mathvariant=bold-italic>κ</mml:mi></mml:mrow></mml:math>B Pathway" @default.
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• W2061176839 doi "https://doi.org/10.1155/2015/735056" @default.
• W2061176839 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4377360" @default.
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