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• W2061179636 abstract "Daptomycin is approved for the treatment of complicated skin and skin-structure infections and Staphylococcus aureus bacteremia. We sought to characterize daptomycin single-dose pharmacokinetics and tolerability in young infants.Subjects < 120 days of age with suspected systemic infections were eligible for inclusion. Each subject was given a single 6 mg/kg intravenous dose of daptomycin. An average of 4 postdose concentrations per infant was obtained.Data from 20 infants are presented. Median gestational age at birth and postnatal age were 32 weeks (range: 23, 40) and 3 days (1, 85), respectively. The median area under the concentration curve at 24 hours, volume of distribution, total body clearance and half-life of daptomycin were 262.4 mg×h/L (166.7, 340.2), 0.21 L/kg (0.11, 0.34), 0.021 L/h/kg (0.016, 0.034) and 6.2 hours (3.7, 9.0), respectively. No adverse events related to daptomycin were observed, including changes in creatine phosphokinase concentrations.Daptomycin clearance in young infants was similar to that in children 2-6 years of age and higher than that observed in adolescents and adults." @default.
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• W2061179636 date "2012-09-01" @default.
• W2061179636 modified "2023-10-14" @default.
• W2061179636 title "Pharmacokinetics and Tolerability of Single-Dose Daptomycin in Young Infants" @default.
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• W2061179636 doi "https://doi.org/10.1097/inf.0b013e31825d2fa2" @default.
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