Matches in SemOpenAlex for { <https://semopenalex.org/work/W2061179661> ?p ?o ?g. }
- W2061179661 endingPage "19" @default.
- W2061179661 startingPage "13" @default.
- W2061179661 abstract "The poor survival rate (5-20%) of grafted embryonic dopamine (DA) neurons is one of the primary factors preventing cell replacement from becoming a viable treatment for Parkinson's disease. Previous studies have demonstrated that graft volume impacts grafted DA neuron survival, indicating that transplant parameters influence survival rates. However, the effects of mesencephalic cell concentration on grafted DA neuron survival have not been investigated. The current study compares the survival rates of DA neurons in grafts of varying concentrations. Mesencephalic cell suspensions derived from E14 Fisher 344 rat pups were concentrated to 25,000, 50,000, 100,000 and 200,000 cells/microl and transplanted into two 0.5 microl sites in the 6-OHDA-denervated rat striatum. Animals were sacrificed 10 days and 6 weeks post-transplantation for histochemical analysis of striatal grafts. The absolute number of DA neurons per graft increased proportionally to the total number of cells transplanted. However, our results show that the 200,000 cells/microl group exhibited significantly higher survival rates (5.48+/-0.83%) compared to the 25,000 cells/microl (2.81+/-0.39%) and 50,000 cells/microl (3.36+/-0.51%) groups (p=0.02 and 0.03, respectively). Soma size of grafted DA neurons in the 200,000 cells/microl group was significantly larger than that of the 25,000 cells/microl (p<0.0001) and 50,000 cells/microl groups (p=0.004). In conclusion, increasing the concentration of mesencephalic cells prior to transplantation, augments the survival and functionality of grafted DA neurons. These data have the potential to identify optimal transplantation parameters that can be applied to procedures utilizing stem cells, neural progenitors, and primary mesencephalic cells." @default.
- W2061179661 created "2016-06-24" @default.
- W2061179661 creator A5033733203 @default.
- W2061179661 creator A5061591117 @default.
- W2061179661 creator A5068387084 @default.
- W2061179661 creator A5080392411 @default.
- W2061179661 creator A5081275808 @default.
- W2061179661 creator A5086053572 @default.
- W2061179661 date "2007-10-01" @default.
- W2061179661 modified "2023-10-18" @default.
- W2061179661 title "Increased cell suspension concentration augments the survival rate of grafted tyrosine hydroxylase immunoreactive neurons" @default.
- W2061179661 cites W140025526 @default.
- W2061179661 cites W1507375943 @default.
- W2061179661 cites W1536894628 @default.
- W2061179661 cites W1697875586 @default.
- W2061179661 cites W174854816 @default.
- W2061179661 cites W1793787917 @default.
- W2061179661 cites W1965933264 @default.
- W2061179661 cites W1968084077 @default.
- W2061179661 cites W1977707442 @default.
- W2061179661 cites W1984678282 @default.
- W2061179661 cites W1986868939 @default.
- W2061179661 cites W1988486878 @default.
- W2061179661 cites W1992230509 @default.
- W2061179661 cites W1999136928 @default.
- W2061179661 cites W2015205701 @default.
- W2061179661 cites W2019452853 @default.
- W2061179661 cites W2021474417 @default.
- W2061179661 cites W2046250118 @default.
- W2061179661 cites W2047083839 @default.
- W2061179661 cites W2052985697 @default.
- W2061179661 cites W2057452326 @default.
- W2061179661 cites W2060268781 @default.
- W2061179661 cites W2062631963 @default.
- W2061179661 cites W2078270115 @default.
- W2061179661 cites W2082298531 @default.
- W2061179661 cites W2082756577 @default.
- W2061179661 cites W2110065186 @default.
- W2061179661 cites W2124559417 @default.
- W2061179661 cites W2128947188 @default.
- W2061179661 cites W2138462240 @default.
- W2061179661 cites W2143959688 @default.
- W2061179661 cites W2158649743 @default.
- W2061179661 cites W2169263228 @default.
- W2061179661 cites W2175315782 @default.
- W2061179661 cites W2334461448 @default.
- W2061179661 cites W2395631443 @default.
- W2061179661 doi "https://doi.org/10.1016/j.jneumeth.2007.06.022" @default.
- W2061179661 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2067253" @default.
- W2061179661 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17706789" @default.
- W2061179661 hasPublicationYear "2007" @default.
- W2061179661 type Work @default.
- W2061179661 sameAs 2061179661 @default.
- W2061179661 citedByCount "22" @default.
- W2061179661 countsByYear W20611796612012 @default.
- W2061179661 countsByYear W20611796612013 @default.
- W2061179661 countsByYear W20611796612014 @default.
- W2061179661 countsByYear W20611796612015 @default.
- W2061179661 countsByYear W20611796612016 @default.
- W2061179661 countsByYear W20611796612019 @default.
- W2061179661 crossrefType "journal-article" @default.
- W2061179661 hasAuthorship W2061179661A5033733203 @default.
- W2061179661 hasAuthorship W2061179661A5061591117 @default.
- W2061179661 hasAuthorship W2061179661A5068387084 @default.
- W2061179661 hasAuthorship W2061179661A5080392411 @default.
- W2061179661 hasAuthorship W2061179661A5081275808 @default.
- W2061179661 hasAuthorship W2061179661A5086053572 @default.
- W2061179661 hasBestOaLocation W20611796612 @default.
- W2061179661 hasConcept C126322002 @default.
- W2061179661 hasConcept C134018914 @default.
- W2061179661 hasConcept C137183658 @default.
- W2061179661 hasConcept C1491633281 @default.
- W2061179661 hasConcept C159167319 @default.
- W2061179661 hasConcept C16685009 @default.
- W2061179661 hasConcept C169760540 @default.
- W2061179661 hasConcept C2776283816 @default.
- W2061179661 hasConcept C2777288102 @default.
- W2061179661 hasConcept C2778794669 @default.
- W2061179661 hasConcept C2780062018 @default.
- W2061179661 hasConcept C2780938664 @default.
- W2061179661 hasConcept C2911091166 @default.
- W2061179661 hasConcept C3019137385 @default.
- W2061179661 hasConcept C513476851 @default.
- W2061179661 hasConcept C54355233 @default.
- W2061179661 hasConcept C55493867 @default.
- W2061179661 hasConcept C71924100 @default.
- W2061179661 hasConcept C81885089 @default.
- W2061179661 hasConcept C86803240 @default.
- W2061179661 hasConceptScore W2061179661C126322002 @default.
- W2061179661 hasConceptScore W2061179661C134018914 @default.
- W2061179661 hasConceptScore W2061179661C137183658 @default.
- W2061179661 hasConceptScore W2061179661C1491633281 @default.
- W2061179661 hasConceptScore W2061179661C159167319 @default.
- W2061179661 hasConceptScore W2061179661C16685009 @default.
- W2061179661 hasConceptScore W2061179661C169760540 @default.
- W2061179661 hasConceptScore W2061179661C2776283816 @default.
- W2061179661 hasConceptScore W2061179661C2777288102 @default.
- W2061179661 hasConceptScore W2061179661C2778794669 @default.