FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2061187116> ?p ?o ?g. }

• W2061187116 endingPage "1919" @default.
• W2061187116 startingPage "1915" @default.
• W2061187116 abstract "The mammalian immune response to infection is mediated by 2 broad arms, the innate and adaptive immune systems. Innate immune cells are a first-line defense against pathogens and are thought to respond consistently to infection, regardless of previous exposure, i.e., they do not exhibit memory of prior activation. By contrast, adaptive immune cells display immunologic memory that has 2 basic characteristics, antigen specificity and an amplified response upon subsequent exposure. Whereas adaptive immune cells have rearranged receptor genes to recognize the universe of antigens, natural killer (NK) cells are innate immune lymphocytes with a limited repertoire of germ-line encoded receptors for target recognition. NK cells also produce cytokines such as IFN-gamma (IFN-γ) to protect the host during the innate response to infection. Herein, we show that cytokine-activated NK cells transferred into naïve hosts can be specifically detected 7–22 days later when they are phenotypically similar to naïve cells and are not constitutively producing IFN-γ. However, they produce significantly more IFN-γ when restimulated. This memory-like property is intrinsic to the NK cell. By contrast, memory-like NK cells do not express granzyme B protein and kill targets similarly to naïve NK cells. Thus, these experiments identify an ability of innate immune cells to retain an intrinsic memory of prior activation, a function until now attributed only to antigen-specific adaptive immune cells." @default.
• W2061187116 created "2016-06-24" @default.
• W2061187116 creator A5010812501 @default.
• W2061187116 creator A5019023491 @default.
• W2061187116 creator A5059127312 @default.
• W2061187116 creator A5069074559 @default.
• W2061187116 creator A5069522130 @default.
• W2061187116 creator A5089034331 @default.
• W2061187116 date "2009-02-10" @default.
• W2061187116 modified "2023-10-05" @default.
• W2061187116 title "Cytokine-induced memory-like natural killer cells" @default.
• W2061187116 cites W1899804292 @default.
• W2061187116 cites W1964742561 @default.
• W2061187116 cites W1968321644 @default.
• W2061187116 cites W1972452655 @default.
• W2061187116 cites W1976611543 @default.
• W2061187116 cites W1983996935 @default.
• W2061187116 cites W2000115037 @default.
• W2061187116 cites W2002597665 @default.
• W2061187116 cites W2003220523 @default.
• W2061187116 cites W2008221423 @default.
• W2061187116 cites W2011528191 @default.
• W2061187116 cites W2020313517 @default.
• W2061187116 cites W2022230965 @default.
• W2061187116 cites W2034412119 @default.
• W2061187116 cites W2040914801 @default.
• W2061187116 cites W2042295185 @default.
• W2061187116 cites W2042728577 @default.
• W2061187116 cites W2088191325 @default.
• W2061187116 cites W2091301099 @default.
• W2061187116 cites W2095326716 @default.
• W2061187116 cites W2096449627 @default.
• W2061187116 cites W2116120252 @default.
• W2061187116 cites W2133449490 @default.
• W2061187116 cites W2135534388 @default.
• W2061187116 cites W2143308086 @default.
• W2061187116 cites W2148077170 @default.
• W2061187116 cites W2171376237 @default.
• W2061187116 cites W2171709048 @default.
• W2061187116 doi "https://doi.org/10.1073/pnas.0813192106" @default.
• W2061187116 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2644138" @default.
• W2061187116 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19181844" @default.
• W2061187116 hasPublicationYear "2009" @default.
• W2061187116 type Work @default.
• W2061187116 sameAs 2061187116 @default.
• W2061187116 citedByCount "648" @default.
• W2061187116 countsByYear W20611871162012 @default.
• W2061187116 countsByYear W20611871162013 @default.
• W2061187116 countsByYear W20611871162014 @default.
• W2061187116 countsByYear W20611871162015 @default.
• W2061187116 countsByYear W20611871162016 @default.
• W2061187116 countsByYear W20611871162017 @default.
• W2061187116 countsByYear W20611871162018 @default.
• W2061187116 countsByYear W20611871162019 @default.
• W2061187116 countsByYear W20611871162020 @default.
• W2061187116 countsByYear W20611871162021 @default.
• W2061187116 countsByYear W20611871162022 @default.
• W2061187116 countsByYear W20611871162023 @default.
• W2061187116 crossrefType "journal-article" @default.
• W2061187116 hasAuthorship W2061187116A5010812501 @default.
• W2061187116 hasAuthorship W2061187116A5019023491 @default.
• W2061187116 hasAuthorship W2061187116A5059127312 @default.
• W2061187116 hasAuthorship W2061187116A5069074559 @default.
• W2061187116 hasAuthorship W2061187116A5069522130 @default.
• W2061187116 hasAuthorship W2061187116A5089034331 @default.
• W2061187116 hasBestOaLocation W20611871161 @default.
• W2061187116 hasConcept C129374314 @default.
• W2061187116 hasConcept C136449434 @default.
• W2061187116 hasConcept C139563560 @default.
• W2061187116 hasConcept C145558887 @default.
• W2061187116 hasConcept C147483822 @default.
• W2061187116 hasConcept C149532602 @default.
• W2061187116 hasConcept C154317977 @default.
• W2061187116 hasConcept C193419808 @default.
• W2061187116 hasConcept C202751555 @default.
• W2061187116 hasConcept C203014093 @default.
• W2061187116 hasConcept C206191192 @default.
• W2061187116 hasConcept C2776090121 @default.
• W2061187116 hasConcept C2778690821 @default.
• W2061187116 hasConcept C2780380082 @default.
• W2061187116 hasConcept C47742525 @default.
• W2061187116 hasConcept C55493867 @default.
• W2061187116 hasConcept C67662055 @default.
• W2061187116 hasConcept C86803240 @default.
• W2061187116 hasConcept C8891405 @default.
• W2061187116 hasConcept C95444343 @default.
• W2061187116 hasConceptScore W2061187116C129374314 @default.
• W2061187116 hasConceptScore W2061187116C136449434 @default.
• W2061187116 hasConceptScore W2061187116C139563560 @default.
• W2061187116 hasConceptScore W2061187116C145558887 @default.
• W2061187116 hasConceptScore W2061187116C147483822 @default.
• W2061187116 hasConceptScore W2061187116C149532602 @default.
• W2061187116 hasConceptScore W2061187116C154317977 @default.
• W2061187116 hasConceptScore W2061187116C193419808 @default.
• W2061187116 hasConceptScore W2061187116C202751555 @default.
• W2061187116 hasConceptScore W2061187116C203014093 @default.
• W2061187116 hasConceptScore W2061187116C206191192 @default.
• W2061187116 hasConceptScore W2061187116C2776090121 @default.

• next