FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2061187654> ?p ?o ?g. }

• W2061187654 endingPage "632" @default.
• W2061187654 startingPage "625" @default.
• W2061187654 abstract "Objective: 5′ deiodination of thyroid hormone represents an important step in the modulation of the hormonal message. Previous studies indicate that the naturally occurring polymorphism located in 5′-untranslated region of the gene, 258 A/G, is associated with a decrease in circulating T4/T3 ratio, suggesting an increased gene expression. The aim of this study was to characterize the gene variant in vitro. Design: This was designed as an in vitro study. Main outcome: The wild-type and mutant promoters were cloned into a reporter vector and transfected into HEK-293, GH3, and H3B cells. Compared to the 258G wild-type allele, the 258A variant had an increased basal activity in all the cell lines (HEK-293 258A 13998 ± 371.9 RLU vs. 258G 5593 ± 124.2 RLU, p < 0.0001). Electrophoresis mobility shift assay (EMSA) experiments were performed with nuclear extracts obtained from HEK-293 cells and from human thyroid, muscle, and liver. The EMSA experiments showed that the 258A variant decreased the binding ability of a nuclear protein in HEK-293 cells, thyroid, and muscle. No specific binding was observed in liver nuclei. Conclusion: These data suggest that the increase in gene transcription induced by the 258A polymorphism could be mediated by reduction in the binding ability of a putative nuclear repressor." @default.
• W2061187654 created "2016-06-24" @default.
• W2061187654 creator A5013839560 @default.
• W2061187654 creator A5043833309 @default.
• W2061187654 creator A5049561179 @default.
• W2061187654 creator A5060204549 @default.
• W2061187654 creator A5086111757 @default.
• W2061187654 date "2006-07-01" @default.
• W2061187654 modified "2023-09-26" @default.
• W2061187654 title "Functional Characterization of the 258 A/G (D2-ORFa-Gly3Asp) Human Type-2 Deiodinase Polymorphism: A Naturally Occurring Variant Increases the Enzymatic Activity by Removing a Putative Repressor Site in the 5′ UTR of the Gene" @default.
• W2061187654 cites W1965534308 @default.
• W2061187654 cites W1974498951 @default.
• W2061187654 cites W1995327555 @default.
• W2061187654 cites W2024675721 @default.
• W2061187654 cites W2029653372 @default.
• W2061187654 cites W2038357159 @default.
• W2061187654 cites W2042451650 @default.
• W2061187654 cites W2045348184 @default.
• W2061187654 cites W2079635977 @default.
• W2061187654 cites W2081028309 @default.
• W2061187654 cites W2098101263 @default.
• W2061187654 cites W2102981095 @default.
• W2061187654 cites W2103576208 @default.
• W2061187654 cites W2110110130 @default.
• W2061187654 cites W2124123171 @default.
• W2061187654 cites W2127811896 @default.
• W2061187654 cites W2139687434 @default.
• W2061187654 cites W2142718693 @default.
• W2061187654 cites W2148290320 @default.
• W2061187654 cites W2148522823 @default.
• W2061187654 cites W2152847902 @default.
• W2061187654 cites W2160166542 @default.
• W2061187654 cites W2166554867 @default.
• W2061187654 cites W2169118951 @default.
• W2061187654 cites W4236943954 @default.
• W2061187654 cites W4250722013 @default.
• W2061187654 cites W4251866877 @default.
• W2061187654 cites W4252145460 @default.
• W2061187654 cites W4252151147 @default.
• W2061187654 doi "https://doi.org/10.1089/thy.2006.16.625" @default.
• W2061187654 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16889485" @default.
• W2061187654 hasPublicationYear "2006" @default.
• W2061187654 type Work @default.
• W2061187654 sameAs 2061187654 @default.
• W2061187654 citedByCount "26" @default.
• W2061187654 countsByYear W20611876542012 @default.
• W2061187654 countsByYear W20611876542013 @default.
• W2061187654 countsByYear W20611876542014 @default.
• W2061187654 countsByYear W20611876542015 @default.
• W2061187654 countsByYear W20611876542017 @default.
• W2061187654 countsByYear W20611876542020 @default.
• W2061187654 countsByYear W20611876542022 @default.
• W2061187654 countsByYear W20611876542023 @default.
• W2061187654 crossrefType "journal-article" @default.
• W2061187654 hasAuthorship W2061187654A5013839560 @default.
• W2061187654 hasAuthorship W2061187654A5043833309 @default.
• W2061187654 hasAuthorship W2061187654A5049561179 @default.
• W2061187654 hasAuthorship W2061187654A5060204549 @default.
• W2061187654 hasAuthorship W2061187654A5086111757 @default.
• W2061187654 hasConcept C101762097 @default.
• W2061187654 hasConcept C104317684 @default.
• W2061187654 hasConcept C143065580 @default.
• W2061187654 hasConcept C150194340 @default.
• W2061187654 hasConcept C153911025 @default.
• W2061187654 hasConcept C158448853 @default.
• W2061187654 hasConcept C161733203 @default.
• W2061187654 hasConcept C174510640 @default.
• W2061187654 hasConcept C183978625 @default.
• W2061187654 hasConcept C202751555 @default.
• W2061187654 hasConcept C207583985 @default.
• W2061187654 hasConcept C54009773 @default.
• W2061187654 hasConcept C54355233 @default.
• W2061187654 hasConcept C86339819 @default.
• W2061187654 hasConcept C86803240 @default.
• W2061187654 hasConceptScore W2061187654C101762097 @default.
• W2061187654 hasConceptScore W2061187654C104317684 @default.
• W2061187654 hasConceptScore W2061187654C143065580 @default.
• W2061187654 hasConceptScore W2061187654C150194340 @default.
• W2061187654 hasConceptScore W2061187654C153911025 @default.
• W2061187654 hasConceptScore W2061187654C158448853 @default.
• W2061187654 hasConceptScore W2061187654C161733203 @default.
• W2061187654 hasConceptScore W2061187654C174510640 @default.
• W2061187654 hasConceptScore W2061187654C183978625 @default.
• W2061187654 hasConceptScore W2061187654C202751555 @default.
• W2061187654 hasConceptScore W2061187654C207583985 @default.
• W2061187654 hasConceptScore W2061187654C54009773 @default.
• W2061187654 hasConceptScore W2061187654C54355233 @default.
• W2061187654 hasConceptScore W2061187654C86339819 @default.
• W2061187654 hasConceptScore W2061187654C86803240 @default.
• W2061187654 hasIssue "7" @default.
• W2061187654 hasLocation W20611876541 @default.
• W2061187654 hasLocation W20611876542 @default.
• W2061187654 hasOpenAccess W2061187654 @default.
• W2061187654 hasPrimaryLocation W20611876541 @default.
• W2061187654 hasRelatedWork W2042364198 @default.
• W2061187654 hasRelatedWork W2074672256 @default.
• W2061187654 hasRelatedWork W2082926700 @default.
• W2061187654 hasRelatedWork W2102196701 @default.

• next