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- W2061189838 abstract "The injection of parental strain cells into adrenalectomized (CBA x A)F1 mice induced a graft-versus-host (GVH) reaction which was morphologically characterized by thymus epithelial cell injury but not stress-related thymic involution. Thymocytes from mice undergoing a GVH reaction were studied for their ability to reconstitute allograft reactivity in thymectomized, irradiated, bone marrow reconstituted (ATxBM) (CBA x A)F1 mice. Thymocytes of mice experiencing a GVH reaction were theta-positive during the course of the reaction, however, by 40 days after GVH induction these thymocytes were unable to reconstitute allograft reactivity to H-2-incompatible skin grafts. It is proposed that GVH-induced thymic epithelial cell injury prevents or arrests normal T cell differentiation, resulting in a population of thymocytes which lack complete functional capability." @default.
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- W2061189838 date "1980-01-01" @default.
- W2061189838 modified "2023-09-27" @default.
- W2061189838 title "T CELL FUNCTIONAL DEFECT ASSOCIATED WITH THYMIC EPITHELIAL CELL INJURY INDUCED BY A GRAFT-VERSUS-HOST REACTION" @default.
- W2061189838 doi "https://doi.org/10.1097/00007890-198001000-00013" @default.
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