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- W2061191109 abstract "Objective To determine if treatment with pentoxifylline would decrease the tissue injury that occurs in a normotensive model of sepsis. Design Random assignment to control, cecal ligation-perforation, or cecal ligation-perforation plus pentoxifylline groups for a 24-hr study. Setting Animal laboratory. Subjects Male Sprague-Dawley rats. Interventions Sepsis was induced by cecal ligation-perforation with aggressive fluid resuscitation (normal saline 10 mL/kg/hr). Pentoxifylline was administered as a 2-mg/kg bolus, followed by a continuous infusion of 6 mg/kg/hr. Measurements and Main Results Compared with controls, rats in the cecal ligation-perforation group had an increased heart rate (432 plus minus 12 vs. 399 plus minus 10 beats/min) and respiratory rate (129 plus minus 6 vs. 94 plus minus 7 breaths/min). Blood pressure was slightly decreased (104 plus minus 4 vs. 125 plus minus 5 mm Hg), while cardiac index was not significantly different (50.1 plus minus 5.7 vs. 40.7 plus minus 3.9 mL/min/100 g). Blood pressure (103 plus minus 4 mm Hg) was the only parameter that was significantly different in the cecal ligation-perforation plus pentoxifylline group compared with controls. When compared with controls, tissue wet/dry weight ratios were increased in the diaphragm of the cecal ligation-perforation group and in the liver, pancreas, small bowel, and large bowel of the cecal ligation-perforation, and the cecal ligation-perforation plus pentoxifylline groups. Tissue/plasma albumin ratios were increased in the diaphragm of the cecal ligation-perforation group and in the liver, pancreas, and large bowel of the cecal ligation-perforation and the cecal ligation-perforation plus pentoxifylline groups. There were no significant differences between the cecal ligation-perforation and the cecal ligation-perforation plus pentoxifylline groups. Conclusions Normotensive sepsis is accompanied by increased vascular permeability in the diaphragm and intra-abdominal organs. Pentoxifylline appears to attenuate some of the systemic manifestations of sepsis. However, pentoxifylline did not prevent the development of protein-rich tissue edema. (Crit Care Med 1995; 23:119-124)" @default.
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- W2061191109 date "1995-01-01" @default.
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- W2061191109 title "Pentoxifylline does not prevent microvascular injury in normotensive, septic rats" @default.
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- W2061191109 doi "https://doi.org/10.1097/00003246-199501000-00020" @default.
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