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- W2061192893 endingPage "12" @default.
- W2061192893 startingPage "3" @default.
- W2061192893 abstract "The incidence of Alzheimer's disease (AD) in individuals >65 years of age is 13% and ~66 million individuals in this age group undergo surgery annually under anesthesia. It is therefore important to determine whether commonly used inhaled anesthetics induce cytotoxicity, which may lead to neurodegeneration. Findings from several studies suggest that the anesthetics, isoflurane, sevoflurane and desflurane, may activate caspases, increase the synthesis and accumulation of β-amyloid (Aβ) protein, and induce hyperphosphorylation of tau proteins, all of which are cellular responses consistent with the neuropathogenesis of AD. Other studies have arrived at different and occasionally contradictory conclusions. The present review attempts to resolve this discrepancy by reviewing previous studies, which have investigated the effects of commonly used inhaled anesthetics on the synthesis and accumulation of Aβ, tau pathology and cognitive function. The possible underlying mechanism was also reviewed. However, several aspects of this phenomenon remain to be elucidated. Further studies are required to fully examine anesthesia-induced neurotoxicity and elucidate the effect of inhaled anesthetics on the onset and progression of AD." @default.
- W2061192893 created "2016-06-24" @default.
- W2061192893 creator A5088189613 @default.
- W2061192893 creator A5090178654 @default.
- W2061192893 date "2015-03-04" @default.
- W2061192893 modified "2023-10-16" @default.
- W2061192893 title "Effect of the inhaled anesthetics isoflurane, sevoflurane and desflurane on the neuropathogenesis of Alzheimer’s disease (Review)" @default.
- W2061192893 cites W1515449698 @default.
- W2061192893 cites W1574697207 @default.
- W2061192893 cites W157501186 @default.
- W2061192893 cites W1600934558 @default.
- W2061192893 cites W1602771322 @default.
- W2061192893 cites W1611407165 @default.
- W2061192893 cites W1729585270 @default.
- W2061192893 cites W1841224192 @default.
- W2061192893 cites W1895241692 @default.
- W2061192893 cites W1931200394 @default.
- W2061192893 cites W1964007188 @default.
- W2061192893 cites W1965135056 @default.
- W2061192893 cites W1967464880 @default.
- W2061192893 cites W1970013295 @default.
- W2061192893 cites W1971116512 @default.
- W2061192893 cites W1972364189 @default.
- W2061192893 cites W1972567838 @default.
- W2061192893 cites W1980825524 @default.
- W2061192893 cites W1985871594 @default.
- W2061192893 cites W1992529596 @default.
- W2061192893 cites W1994030229 @default.
- W2061192893 cites W1994372868 @default.
- W2061192893 cites W1996080061 @default.
- W2061192893 cites W1997031697 @default.
- W2061192893 cites W1997370803 @default.
- W2061192893 cites W2000153817 @default.
- W2061192893 cites W2004541006 @default.
- W2061192893 cites W2006802243 @default.
- W2061192893 cites W2009468295 @default.
- W2061192893 cites W2011092266 @default.
- W2061192893 cites W2015603520 @default.
- W2061192893 cites W2016928060 @default.
- W2061192893 cites W2017000348 @default.
- W2061192893 cites W2017950146 @default.
- W2061192893 cites W2018342879 @default.
- W2061192893 cites W2021312655 @default.
- W2061192893 cites W2021474822 @default.
- W2061192893 cites W2021635886 @default.
- W2061192893 cites W2022532556 @default.
- W2061192893 cites W2028403300 @default.
- W2061192893 cites W2030567293 @default.
- W2061192893 cites W2031851629 @default.
- W2061192893 cites W2032232498 @default.
- W2061192893 cites W2042148434 @default.
- W2061192893 cites W2042955975 @default.
- W2061192893 cites W2046948369 @default.
- W2061192893 cites W2048865592 @default.
- W2061192893 cites W2049992435 @default.
- W2061192893 cites W2051964585 @default.
- W2061192893 cites W2053535174 @default.
- W2061192893 cites W2054388625 @default.
- W2061192893 cites W2054542987 @default.
- W2061192893 cites W2057013121 @default.
- W2061192893 cites W2057709960 @default.
- W2061192893 cites W2059390957 @default.
- W2061192893 cites W2059632759 @default.
- W2061192893 cites W2062193929 @default.
- W2061192893 cites W2063193894 @default.
- W2061192893 cites W2066343710 @default.
- W2061192893 cites W2073038188 @default.
- W2061192893 cites W2074175204 @default.
- W2061192893 cites W2075466397 @default.
- W2061192893 cites W2077859404 @default.
- W2061192893 cites W2078503498 @default.
- W2061192893 cites W2079777478 @default.
- W2061192893 cites W2080337097 @default.
- W2061192893 cites W2080562696 @default.
- W2061192893 cites W2080779842 @default.
- W2061192893 cites W2082399239 @default.
- W2061192893 cites W2082429191 @default.
- W2061192893 cites W2085409469 @default.
- W2061192893 cites W2088881960 @default.
- W2061192893 cites W2090221075 @default.
- W2061192893 cites W2092926605 @default.
- W2061192893 cites W2095082499 @default.
- W2061192893 cites W2096278785 @default.
- W2061192893 cites W2096410114 @default.
- W2061192893 cites W2097965815 @default.
- W2061192893 cites W2098267895 @default.
- W2061192893 cites W2100557509 @default.
- W2061192893 cites W2104096720 @default.
- W2061192893 cites W2104898383 @default.
- W2061192893 cites W2109958697 @default.
- W2061192893 cites W2111040212 @default.
- W2061192893 cites W2116489922 @default.
- W2061192893 cites W2117625001 @default.
- W2061192893 cites W2120795431 @default.
- W2061192893 cites W2122320288 @default.
- W2061192893 cites W2124390363 @default.
- W2061192893 cites W2126279450 @default.
- W2061192893 cites W2127363445 @default.