FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2061193669> ?p ?o ?g. }

• W2061193669 abstract "Abstract Members of the Notch family of transmembrane receptors, Notch1-4 in mammals, are involved in the regulation of cell fate decisions and cell proliferation in various organisms. The Notch4 isoform, which is specific to mammals, was originally identified as a viral oncogene in mice, Int3, able to initiate mammary tumors. In humans, Notch4 expression appears to be associated with breast cancer stem cells and endocrine resistance. Following ligand binding, the Notch4 receptor undergoes cleavage at the membrane and the Notch4-intracellular domain (ICD), translocates to the nucleus and regulates gene transcription. Little is known on the mechanisms regulating Notch4-ICD and its nuclear localization. Here, we describe the identification of four distinct AKT phosphorylation sites in human Notch4-ICD and demonstrate that AKT binds Notch4-ICD and phosphorylates all four sites in vitro and in vivo . The phosphorylation in cells is regulated by growth factors and is sensitive to phosphatidyl inositol-3 kinase (PI3K) inhibitors. This phosphorylation generates binding sites to the 14-3-3 regulatory proteins, which are involved in the regulation of nucleocytoplasmic shuttling of target proteins, restricting phosphorylated Notch4-ICD to the cytoplasm. Our findings provide a novel mechanism for Notch4-ICD regulation, suggesting a negative regulatory role for the PI3K-AKT pathway in Notch4 nuclear signaling." @default.
• W2061193669 created "2016-06-24" @default.
• W2061193669 creator A5000005180 @default.
• W2061193669 creator A5003812373 @default.
• W2061193669 creator A5005168657 @default.
• W2061193669 creator A5010173370 @default.
• W2061193669 creator A5024287976 @default.
• W2061193669 creator A5035302490 @default.
• W2061193669 creator A5040506694 @default.
• W2061193669 creator A5041301571 @default.
• W2061193669 creator A5057095327 @default.
• W2061193669 creator A5073617457 @default.
• W2061193669 creator A5081839578 @default.
• W2061193669 date "2015-03-05" @default.
• W2061193669 modified "2023-10-16" @default.
• W2061193669 title "AKT and 14-3-3 Regulate Notch4 Nuclear Localization" @default.
• W2061193669 cites W1814546794 @default.
• W2061193669 cites W1963968051 @default.
• W2061193669 cites W1971571526 @default.
• W2061193669 cites W1972290939 @default.
• W2061193669 cites W1978097298 @default.
• W2061193669 cites W1978221635 @default.
• W2061193669 cites W1983570871 @default.
• W2061193669 cites W1983849161 @default.
• W2061193669 cites W1990283596 @default.
• W2061193669 cites W1990543711 @default.
• W2061193669 cites W1997801717 @default.
• W2061193669 cites W2006902704 @default.
• W2061193669 cites W2011400826 @default.
• W2061193669 cites W2012426719 @default.
• W2061193669 cites W2031350022 @default.
• W2061193669 cites W2032095580 @default.
• W2061193669 cites W2042805701 @default.
• W2061193669 cites W2048168473 @default.
• W2061193669 cites W2052531721 @default.
• W2061193669 cites W2053584319 @default.
• W2061193669 cites W2075357740 @default.
• W2061193669 cites W2077845548 @default.
• W2061193669 cites W2085037886 @default.
• W2061193669 cites W2091212411 @default.
• W2061193669 cites W2096576561 @default.
• W2061193669 cites W2099445963 @default.
• W2061193669 cites W2105891671 @default.
• W2061193669 cites W2109686686 @default.
• W2061193669 cites W2112348715 @default.
• W2061193669 cites W2115504447 @default.
• W2061193669 cites W2120165846 @default.
• W2061193669 cites W2123478725 @default.
• W2061193669 cites W2123922689 @default.
• W2061193669 cites W2133943800 @default.
• W2061193669 cites W2146660065 @default.
• W2061193669 cites W2158453397 @default.
• W2061193669 cites W2160455157 @default.
• W2061193669 cites W4240748016 @default.
• W2061193669 doi "https://doi.org/10.1038/srep08782" @default.
• W2061193669 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4350099" @default.
• W2061193669 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25740432" @default.
• W2061193669 hasPublicationYear "2015" @default.
• W2061193669 type Work @default.
• W2061193669 sameAs 2061193669 @default.
• W2061193669 citedByCount "23" @default.
• W2061193669 countsByYear W20611936692015 @default.
• W2061193669 countsByYear W20611936692016 @default.
• W2061193669 countsByYear W20611936692017 @default.
• W2061193669 countsByYear W20611936692018 @default.
• W2061193669 countsByYear W20611936692019 @default.
• W2061193669 countsByYear W20611936692020 @default.
• W2061193669 countsByYear W20611936692021 @default.
• W2061193669 countsByYear W20611936692022 @default.
• W2061193669 crossrefType "journal-article" @default.
• W2061193669 hasAuthorship W2061193669A5000005180 @default.
• W2061193669 hasAuthorship W2061193669A5003812373 @default.
• W2061193669 hasAuthorship W2061193669A5005168657 @default.
• W2061193669 hasAuthorship W2061193669A5010173370 @default.
• W2061193669 hasAuthorship W2061193669A5024287976 @default.
• W2061193669 hasAuthorship W2061193669A5035302490 @default.
• W2061193669 hasAuthorship W2061193669A5040506694 @default.
• W2061193669 hasAuthorship W2061193669A5041301571 @default.
• W2061193669 hasAuthorship W2061193669A5057095327 @default.
• W2061193669 hasAuthorship W2061193669A5073617457 @default.
• W2061193669 hasAuthorship W2061193669A5081839578 @default.
• W2061193669 hasBestOaLocation W20611936691 @default.
• W2061193669 hasConcept C104317684 @default.
• W2061193669 hasConcept C11960822 @default.
• W2061193669 hasConcept C161879069 @default.
• W2061193669 hasConcept C54355233 @default.
• W2061193669 hasConcept C62478195 @default.
• W2061193669 hasConcept C63932345 @default.
• W2061193669 hasConcept C75217442 @default.
• W2061193669 hasConcept C86339819 @default.
• W2061193669 hasConcept C86554907 @default.
• W2061193669 hasConcept C86803240 @default.
• W2061193669 hasConcept C95444343 @default.
• W2061193669 hasConceptScore W2061193669C104317684 @default.
• W2061193669 hasConceptScore W2061193669C11960822 @default.
• W2061193669 hasConceptScore W2061193669C161879069 @default.
• W2061193669 hasConceptScore W2061193669C54355233 @default.
• W2061193669 hasConceptScore W2061193669C62478195 @default.
• W2061193669 hasConceptScore W2061193669C63932345 @default.
• W2061193669 hasConceptScore W2061193669C75217442 @default.

• next