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• W2061193761 endingPage "e246" @default.
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• W2061193761 abstract "Differential transcription in Ascaris suum was investigated using a genomic-bioinformatic approach. A cDNA archive enriched for molecules in the infective third-stage larva (L3) of A. suum was constructed by suppressive-subtractive hybridization (SSH), and a subset of cDNAs from 3075 clones subjected to microarray analysis using cDNA probes derived from RNA from different developmental stages of A. suum. The cDNAs (n = 498) shown by microarray analysis to be enriched in the L3 were sequenced and subjected to bioinformatic analyses using a semi-automated pipeline (ESTExplorer). Using gene ontology (GO), 235 of these molecules were assigned to 'biological process' (n = 68), 'cellular component' (n = 50), or 'molecular function' (n = 117). Of the 91 clusters assembled, 56 molecules (61.5%) had homologues/orthologues in the free-living nematodes Caenorhabditis elegans and C. briggsae and/or other organisms, whereas 35 (38.5%) had no significant similarity to any sequences available in current gene databases. Transcripts encoding protein kinases, protein phosphatases (and their precursors), and enolases were abundantly represented in the L3 of A. suum, as were molecules involved in cellular processes, such as ubiquitination and proteasome function, gene transcription, protein-protein interactions, and function. In silico analyses inferred the C. elegans orthologues/homologues (n = 50) to be involved in apoptosis and insulin signaling (2%), ATP synthesis (2%), carbon metabolism (6%), fatty acid biosynthesis (2%), gap junction (2%), glucose metabolism (6%), or porphyrin metabolism (2%), although 34 (68%) of them could not be mapped to a specific metabolic pathway. Small numbers of these 50 molecules were predicted to be secreted (10%), anchored (2%), and/or transmembrane (12%) proteins. Functionally, 17 (34%) of them were predicted to be associated with (non-wild-type) RNAi phenotypes in C. elegans, the majority being embryonic lethality (Emb) (13 types; 58.8%), larval arrest (Lva) (23.5%) and larval lethality (Lvl) (47%). A genetic interaction network was predicted for these 17 C. elegans orthologues, revealing highly significant interactions for nine molecules associated with embryonic and larval development (66.9%), information storage and processing (5.1%), cellular processing and signaling (15.2%), metabolism (6.1%), and unknown function (6.7%). The potential roles of these molecules in development are discussed in relation to the known roles of their homologues/orthologues in C. elegans and some other nematodes. The results of the present study provide a basis for future functional genomic studies to elucidate molecular aspects governing larval developmental processes in A. suum and/or the transition to parasitism." @default.
• W2061193761 created "2016-06-24" @default.
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• W2061193761 date "2008-06-18" @default.
• W2061193761 modified "2023-10-18" @default.
• W2061193761 title "Genomic-Bioinformatic Analysis of Transcripts Enriched in the Third-Stage Larva of the Parasitic Nematode Ascaris suum" @default.
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• W2061193761 cites W1965070096 @default.
• W2061193761 cites W1968792770 @default.
• W2061193761 cites W1976057810 @default.
• W2061193761 cites W1978485827 @default.
• W2061193761 cites W1998653602 @default.
• W2061193761 cites W2004070693 @default.
• W2061193761 cites W2006117889 @default.
• W2061193761 cites W2016795682 @default.
• W2061193761 cites W2020326923 @default.
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• W2061193761 cites W2033443117 @default.
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• W2061193761 cites W2038515449 @default.
• W2061193761 cites W2041797719 @default.
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• W2061193761 cites W2047480447 @default.
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• W2061193761 cites W2100668965 @default.
• W2061193761 cites W2102201378 @default.
• W2061193761 cites W2103017472 @default.
• W2061193761 cites W2107678710 @default.
• W2061193761 cites W2111119053 @default.
• W2061193761 cites W2112928083 @default.
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• W2061193761 cites W2139902443 @default.
• W2061193761 cites W2141573080 @default.
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• W2061193761 doi "https://doi.org/10.1371/journal.pntd.0000246" @default.
• W2061193761 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2398786" @default.
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