FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2061202302> ?p ?o ?g. }

• W2061202302 endingPage "262" @default.
• W2061202302 startingPage "257" @default.
• W2061202302 abstract "Recent studies have suggested that bile acid acyl glucuronides form covalently bound protein adducts which may cause hypersensitivity reactions and increased morbidity in patients. Although the preferential biosynthesis of the acyl glucuronides has been known, the characterization of hepatic bile acid acyl glucuronosyltransferase has not yet been clearly elucidated. We have investigated the substrate specificity of the hepatic bile acid acyl glucuronosyltransferase using five common bile acids as substrates. The glucuronidation rate was dependent on the number of the hydroxy group on the steroid nucleus and mono-hydroxylated lithocholic acid, the more lipophilic common bile acid, was most effectively metabolized into its acyl glucuronide. The tri-hydroxylated cholic acid, the more water-soluble common bile acid, barely transformed into its glucuronide. Results showed decreasing of the initial velocity of the acyl glucuronidation with increasing of the concentration of substrate, lithocholic acid, owing to the substrate inhibition of the hepatic bile acid acyl glucuronosyltransferase. The substrate analogues, glycine and taurine conjugated bile acids, which exist in the body fluids in high concentrations, also inhibited the enzyme's activity. In addition, enzymatic reaction products, bile acid acyl glucuronides, also inhibited the activity. These inhibitory mechanisms may be responsible for the low concentration of bile acid acyl glucuronides in urine and may be an important detoxification system in the body." @default.
• W2061202302 created "2016-06-24" @default.
• W2061202302 creator A5002410791 @default.
• W2061202302 creator A5032108002 @default.
• W2061202302 creator A5032445401 @default.
• W2061202302 creator A5053524893 @default.
• W2061202302 creator A5063732330 @default.
• W2061202302 date "2002-03-01" @default.
• W2061202302 modified "2023-09-30" @default.
• W2061202302 title "Characterization of rat liver bile acid acyl glucuronosyltransferase" @default.
• W2061202302 cites W1488332153 @default.
• W2061202302 cites W1587141413 @default.
• W2061202302 cites W1602346713 @default.
• W2061202302 cites W1971630098 @default.
• W2061202302 cites W1982138129 @default.
• W2061202302 cites W1989300686 @default.
• W2061202302 cites W2003821417 @default.
• W2061202302 cites W2006529820 @default.
• W2061202302 cites W2014239314 @default.
• W2061202302 cites W2023800553 @default.
• W2061202302 cites W2030837730 @default.
• W2061202302 cites W2038572958 @default.
• W2061202302 cites W2075015461 @default.
• W2061202302 cites W2075631560 @default.
• W2061202302 cites W2142128644 @default.
• W2061202302 cites W2170866321 @default.
• W2061202302 cites W2276978385 @default.
• W2061202302 cites W2315222771 @default.
• W2061202302 cites W4293247451 @default.
• W2061202302 doi "https://doi.org/10.1016/s0039-128x(01)00162-3" @default.
• W2061202302 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11856549" @default.
• W2061202302 hasPublicationYear "2002" @default.
• W2061202302 type Work @default.
• W2061202302 sameAs 2061202302 @default.
• W2061202302 citedByCount "22" @default.
• W2061202302 countsByYear W20612023022012 @default.
• W2061202302 countsByYear W20612023022018 @default.
• W2061202302 countsByYear W20612023022022 @default.
• W2061202302 crossrefType "journal-article" @default.
• W2061202302 hasAuthorship W2061202302A5002410791 @default.
• W2061202302 hasAuthorship W2061202302A5032108002 @default.
• W2061202302 hasAuthorship W2061202302A5032445401 @default.
• W2061202302 hasAuthorship W2061202302A5053524893 @default.
• W2061202302 hasAuthorship W2061202302A5063732330 @default.
• W2061202302 hasConcept C10213722 @default.
• W2061202302 hasConcept C161790260 @default.
• W2061202302 hasConcept C181199279 @default.
• W2061202302 hasConcept C185592680 @default.
• W2061202302 hasConcept C18903297 @default.
• W2061202302 hasConcept C193557335 @default.
• W2061202302 hasConcept C2775900799 @default.
• W2061202302 hasConcept C2777289219 @default.
• W2061202302 hasConcept C2777756961 @default.
• W2061202302 hasConcept C2779074116 @default.
• W2061202302 hasConcept C2779399885 @default.
• W2061202302 hasConcept C2779701627 @default.
• W2061202302 hasConcept C2779907587 @default.
• W2061202302 hasConcept C2780420665 @default.
• W2061202302 hasConcept C2780902042 @default.
• W2061202302 hasConcept C2781278898 @default.
• W2061202302 hasConcept C515207424 @default.
• W2061202302 hasConcept C55493867 @default.
• W2061202302 hasConcept C71315377 @default.
• W2061202302 hasConcept C86803240 @default.
• W2061202302 hasConcept C87644729 @default.
• W2061202302 hasConceptScore W2061202302C10213722 @default.
• W2061202302 hasConceptScore W2061202302C161790260 @default.
• W2061202302 hasConceptScore W2061202302C181199279 @default.
• W2061202302 hasConceptScore W2061202302C185592680 @default.
• W2061202302 hasConceptScore W2061202302C18903297 @default.
• W2061202302 hasConceptScore W2061202302C193557335 @default.
• W2061202302 hasConceptScore W2061202302C2775900799 @default.
• W2061202302 hasConceptScore W2061202302C2777289219 @default.
• W2061202302 hasConceptScore W2061202302C2777756961 @default.
• W2061202302 hasConceptScore W2061202302C2779074116 @default.
• W2061202302 hasConceptScore W2061202302C2779399885 @default.
• W2061202302 hasConceptScore W2061202302C2779701627 @default.
• W2061202302 hasConceptScore W2061202302C2779907587 @default.
• W2061202302 hasConceptScore W2061202302C2780420665 @default.
• W2061202302 hasConceptScore W2061202302C2780902042 @default.
• W2061202302 hasConceptScore W2061202302C2781278898 @default.
• W2061202302 hasConceptScore W2061202302C515207424 @default.
• W2061202302 hasConceptScore W2061202302C55493867 @default.
• W2061202302 hasConceptScore W2061202302C71315377 @default.
• W2061202302 hasConceptScore W2061202302C86803240 @default.
• W2061202302 hasConceptScore W2061202302C87644729 @default.
• W2061202302 hasFunder F4320320912 @default.
• W2061202302 hasIssue "3-4" @default.
• W2061202302 hasLocation W20612023021 @default.
• W2061202302 hasLocation W20612023022 @default.
• W2061202302 hasOpenAccess W2061202302 @default.
• W2061202302 hasPrimaryLocation W20612023021 @default.
• W2061202302 hasRelatedWork W145230811 @default.
• W2061202302 hasRelatedWork W1590993351 @default.
• W2061202302 hasRelatedWork W1998712380 @default.
• W2061202302 hasRelatedWork W2040019155 @default.
• W2061202302 hasRelatedWork W2042801792 @default.
• W2061202302 hasRelatedWork W2043790430 @default.

• next