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• W2061217223 abstract "the abilities of several aliphatic organohalide compounds to deplete reduced non-protein sulfhydryl (NPS)concentrations in rodent kidney, liver, lung, stomach, and testis were measured. the sites of NPS loss were compared to the sites of tissue injury as documented in previous reports. Single intraperitoneal (i.p.) injections of 1,2-dibromo-3-chloropropane (DBCP), 1,2-dibromoethane (ethylene dibromide, EDB), or hexachloro-1,3-butadiene (HCBD) decreased hepatic and renal NPS concentrations in mice in a dose-related manner. Small NPS losses were produced in lung, testis and stomach, but oniy at high organohalide doses. Administration of tris(2,3-dibromopropyl)phosphate (TRIS) decreased NPS content in liver only. Pretreatments with the enzyme inducer polybrominated biphenyls (PBB) or the enzyme inhibitor piperonyl butoxide quantitatively decreased the renal and hepatic NPS-depleting actions of DBCP or EDB in vivo, but the enzyme inhibitor β-diethylaminoethyl diphenylpropylacetate (SKF 525-A) was without demonstrable effect. the acute, i.p. LD50 value of DBCP was increased by prior treatment of mice with PBB. the LD50 values of DBCP and EDB, however, were unaffected by prior treatment with piperonyl butoxide. DBCP or EDB enhanced the loss of reduced NPS groups from rat hepatic homogenates in vitro; the reaction was time dependent and appeared to be enzyme mediated. Although the primary target organs for DBCP or TRIS toxicity are reported to be the kidney and the testis, the major site of NPS depletion was found to be the liver. Also, HCBD depleted renal NPS in mice only (not rats), though HCBD is nephrotoxic in rats as well as in mice. the correlations between tissue depletion of NPS and sites of organohalide injury, therefore, were poor." @default.
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• W2061217223 date "1981-08-01" @default.
• W2061217223 modified "2023-09-26" @default.
• W2061217223 title "Depletion by 1,2-dibromoethane, 1,2-dibromo-3-chloropropane, tris(2,3-dibromopropyl)phosphate,and hexachloro-1,3-butadiene of reduced non-protein sulfhydryl groups in target and non-target organs" @default.
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• W2061217223 doi "https://doi.org/10.1016/0006-2952(81)90097-6" @default.
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