FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2061220010> ?p ?o ?g. }

• W2061220010 endingPage "3840" @default.
• W2061220010 startingPage "3835" @default.
• W2061220010 abstract "A fundamental and unresolved problem in animal development is the question of how a growing tissue knows when it has achieved its correct final size. A widely held view suggests that this process is controlled by morphogen gradients, which adapt to tissue size and become flatter as tissue grows, leading eventually to growth arrest. Here, we present evidence that the decapentaplegic (Dpp) morphogen distribution in the developing Drosophila wing imaginal disk does not adapt to disk size. We measure the distribution of a functional Dpp-GFP transgene and the Dpp signal transduced by phospho-Mad and show that the characteristic length scale of the Dpp profile remains approximately constant during growth. This finding suggests an alternative scenario of size determination, where disk size is determined relative to the fixed morphogen distribution by a certain threshold level of morphogen required for growth. We propose that when disk boundary reaches the threshold the arrest of cell proliferation throughout the disk is induced by mechanical stress in the tissue. Mechanical stress is expected to arise from the nonuniformity of morphogen distribution that drives growth. This stress, through a negative feedback on growth, can compensate for the nonuniformity of morphogen, achieving uniform growth with the rate that vanishes when disk boundary reaches the threshold. The mechanism is demonstrated through computer simulations of a tissue growth model that identifies the key assumptions and testable predictions. This analysis provides an alternative hypothesis for the size determination process. Novel experimental approaches will be needed to test this model." @default.
• W2061220010 created "2016-06-24" @default.
• W2061220010 creator A5026224980 @default.
• W2061220010 creator A5046043198 @default.
• W2061220010 creator A5052778454 @default.
• W2061220010 creator A5057351444 @default.
• W2061220010 creator A5067307589 @default.
• W2061220010 date "2007-03-06" @default.
• W2061220010 modified "2023-10-17" @default.
• W2061220010 title "On the mechanism of wing size determination in fly development" @default.
• W2061220010 cites W1517998622 @default.
• W2061220010 cites W1567403197 @default.
• W2061220010 cites W1594995183 @default.
• W2061220010 cites W1720193968 @default.
• W2061220010 cites W1838990806 @default.
• W2061220010 cites W1922409394 @default.
• W2061220010 cites W1966875890 @default.
• W2061220010 cites W1968706614 @default.
• W2061220010 cites W1976577398 @default.
• W2061220010 cites W1980878261 @default.
• W2061220010 cites W1981477992 @default.
• W2061220010 cites W1984699863 @default.
• W2061220010 cites W1989117766 @default.
• W2061220010 cites W1989467089 @default.
• W2061220010 cites W1990798651 @default.
• W2061220010 cites W1991100707 @default.
• W2061220010 cites W1992374635 @default.
• W2061220010 cites W1997341464 @default.
• W2061220010 cites W2000618372 @default.
• W2061220010 cites W2000646745 @default.
• W2061220010 cites W2002223490 @default.
• W2061220010 cites W2004961750 @default.
• W2061220010 cites W2009455581 @default.
• W2061220010 cites W2013986963 @default.
• W2061220010 cites W2016350172 @default.
• W2061220010 cites W2021554803 @default.
• W2061220010 cites W2021713419 @default.
• W2061220010 cites W2027424090 @default.
• W2061220010 cites W2030917322 @default.
• W2061220010 cites W2032930150 @default.
• W2061220010 cites W2036980069 @default.
• W2061220010 cites W2037921918 @default.
• W2061220010 cites W2046970439 @default.
• W2061220010 cites W2048917073 @default.
• W2061220010 cites W2049328469 @default.
• W2061220010 cites W2060020667 @default.
• W2061220010 cites W2063753069 @default.
• W2061220010 cites W2069422711 @default.
• W2061220010 cites W2087850490 @default.
• W2061220010 cites W2088574304 @default.
• W2061220010 cites W2092728011 @default.
• W2061220010 cites W2093957890 @default.
• W2061220010 cites W2094271503 @default.
• W2061220010 cites W2098003895 @default.
• W2061220010 cites W2112068069 @default.
• W2061220010 cites W2112499390 @default.
• W2061220010 cites W2113695281 @default.
• W2061220010 cites W2116120836 @default.
• W2061220010 cites W2123117119 @default.
• W2061220010 cites W2128584428 @default.
• W2061220010 cites W2130979840 @default.
• W2061220010 cites W2134735295 @default.
• W2061220010 cites W2138222765 @default.
• W2061220010 cites W2146321861 @default.
• W2061220010 cites W2148294117 @default.
• W2061220010 cites W2151876618 @default.
• W2061220010 cites W2163569157 @default.
• W2061220010 cites W2262152992 @default.
• W2061220010 cites W317249985 @default.
• W2061220010 cites W4239373283 @default.
• W2061220010 doi "https://doi.org/10.1073/pnas.0607134104" @default.
• W2061220010 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1820670" @default.
• W2061220010 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17360439" @default.
• W2061220010 hasPublicationYear "2007" @default.
• W2061220010 type Work @default.
• W2061220010 sameAs 2061220010 @default.
• W2061220010 citedByCount "334" @default.
• W2061220010 countsByYear W20612200102012 @default.
• W2061220010 countsByYear W20612200102013 @default.
• W2061220010 countsByYear W20612200102014 @default.
• W2061220010 countsByYear W20612200102015 @default.
• W2061220010 countsByYear W20612200102016 @default.
• W2061220010 countsByYear W20612200102017 @default.
• W2061220010 countsByYear W20612200102018 @default.
• W2061220010 countsByYear W20612200102019 @default.
• W2061220010 countsByYear W20612200102020 @default.
• W2061220010 countsByYear W20612200102021 @default.
• W2061220010 countsByYear W20612200102022 @default.
• W2061220010 countsByYear W20612200102023 @default.
• W2061220010 crossrefType "journal-article" @default.
• W2061220010 hasAuthorship W2061220010A5026224980 @default.
• W2061220010 hasAuthorship W2061220010A5046043198 @default.
• W2061220010 hasAuthorship W2061220010A5052778454 @default.
• W2061220010 hasAuthorship W2061220010A5057351444 @default.
• W2061220010 hasAuthorship W2061220010A5067307589 @default.
• W2061220010 hasBestOaLocation W20612200101 @default.
• W2061220010 hasConcept C104317684 @default.
• W2061220010 hasConcept C110121322 @default.

• next