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• W2061229416 abstract "Purpose of review Dysregulated coagulation is now recognized as a major contributor to graft loss in xenotransplantation. This review summarizes recent data on putative mechanisms of pathogenic coagulation in xenotransplantation and discusses progress on strategies to overcome them. Recent findings Evidence continues to grow that the primary cause of failure of pig cardiac and renal xenografts is probably antibody-mediated injury to the endothelium, leading to development of microvascular thrombosis. Several factors that may exacerbate the problem will remain, even in the absence of a humoral response. These include molecular incompatibilities that affect the control of coagulation – in particular the failure of pig thrombomodulin to activate the primate protein C pathway – and platelet reactivity. Expression of anticoagulant and antiplatelet molecules within the graft is a potential solution that has been successfully tested in rodent models and will soon be applied to the pig-to-primate model. This strategy, in parallel with physical methods such as encasing islets in a protective layer, also holds promise for reducing the thrombogenicity of pig islet xenografts. Summary Thrombosis is a barrier to long-term survival and function of porcine xenografts, which may eventually be overcome by various combinations of genetic and physical manipulation." @default.
• W2061229416 created "2016-06-24" @default.
• W2061229416 creator A5039238202 @default.
• W2061229416 creator A5067910050 @default.
• W2061229416 date "2008-04-01" @default.
• W2061229416 modified "2023-09-23" @default.
• W2061229416 title "The coagulation barrier in xenotransplantation: incompatibilities and strategies to overcome them" @default.
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• W2061229416 cites W1965306847 @default.
• W2061229416 cites W1967623382 @default.
• W2061229416 cites W1968141871 @default.
• W2061229416 cites W1968587313 @default.
• W2061229416 cites W1969380932 @default.
• W2061229416 cites W1969922813 @default.
• W2061229416 cites W1970127550 @default.
• W2061229416 cites W1972357761 @default.
• W2061229416 cites W1976199229 @default.
• W2061229416 cites W1981445073 @default.
• W2061229416 cites W1981456583 @default.
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• W2061229416 cites W1985407729 @default.
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• W2061229416 cites W2012574456 @default.
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• W2061229416 cites W2014944668 @default.
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• W2061229416 cites W2026097978 @default.
• W2061229416 cites W2033153745 @default.
• W2061229416 cites W2039506748 @default.
• W2061229416 cites W2040682389 @default.
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• W2061229416 cites W2073343515 @default.
• W2061229416 cites W2074332806 @default.
• W2061229416 cites W2083804112 @default.
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• W2061229416 doi "https://doi.org/10.1097/mot.0b013e3282f63c74" @default.
• W2061229416 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18685300" @default.
• W2061229416 hasPublicationYear "2008" @default.
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