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- W2061232372 abstract "The cation ionophore X-537A in the concentration range of 10 −6 to 3 × 10 −5 M produced contractions in the rat and guinea-pig vas deferens. No contractile effect was produced in either of the vasa deferentia preparations by the ionophore A-23187 in the concentration range of 10 −7 to 5 × 10 −5 M. In contrast, X-537A had no contractile effect on the guinea-pig ileal longitudinal smooth muscle while A-23187 produced a dose and [Ca 2+ ] dependent contraction.The contractile effect of X-537A in the vasa deferentia preparations is abolished by phenoxybenzamine or prior reserpine treatment and is therefore attributed to the release of norepinephrine. The effect of A-23187 in the intestinal smooth muscle is attributed to a direct Ca 2+ transporting action since its contractile effect is unaffected by histamine, acetylcholine, or 5-hydroxytryptamine antagonists." @default.
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- W2061232372 date "1975-12-01" @default.
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- W2061232372 title "The Action of the Ionophores, X-537A and A-23187, on Smooth Muscle" @default.
- W2061232372 doi "https://doi.org/10.1139/y75-154" @default.
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