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• W2061236999 abstract "Adipocyte differentiation is tightly controlled by a transcriptional cascade, which directs the extensive reprogramming of gene expression required to convert fibroblast-like precursor cells into mature lipid-laden adipocytes. Recent global analyses of transcription factor binding and chromatin remodeling have revealed 'snapshots' of this cascade and the chromatin landscape at specific time-points of differentiation. These studies demonstrate that multiple adipogenic transcription factors co-occupy hotspots characterized by an open chromatin structure and specific epigenetic modifications. Such transcription factor hotspots are likely to represent key signaling nodes which integrate multiple adipogenic signals at specific chromatin sites, thereby facilitating coordinated action on gene expression." @default.
• W2061236999 created "2016-06-24" @default.
• W2061236999 creator A5035669874 @default.
• W2061236999 creator A5060538191 @default.
• W2061236999 creator A5088475675 @default.
• W2061236999 date "2012-02-01" @default.
• W2061236999 modified "2023-10-09" @default.
• W2061236999 title "Transcriptional networks and chromatin remodeling controlling adipogenesis" @default.
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• W2061236999 doi "https://doi.org/10.1016/j.tem.2011.10.001" @default.
• W2061236999 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22079269" @default.
• W2061236999 hasPublicationYear "2012" @default.
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