Matches in SemOpenAlex for { <https://semopenalex.org/work/W2061255909> ?p ?o ?g. }
- W2061255909 endingPage "1414" @default.
- W2061255909 startingPage "1404" @default.
- W2061255909 abstract "Idiopathic achalasia is an inflammatory disease of unknown etiology characterized by esophageal aperistalsis and failure of LES relaxation due to loss of inhibitory nitrinergic neurons in the esophageal myenteric plexus. Proposed causes of achalasia include gastroesophageal junction obstruction, neuronal degeneration, viral infection, genetic inheritance, and autoimmune disease. Current evidence suggests that the initial insult to the esophagus, perhaps a viral infection or some other environmental factor, results in myenteric plexus inflammation. The inflammation then leads to an autoimmune response in a susceptible population who may be genetically predisposed. Subsequently, chronic inflammation leads to destruction of the inhibitory myenteric ganglion cells resulting in the clinical syndrome of idiopathic achalasia. Further studies are needed to better understand the etiology and pathogenesis of achalasia—such an understanding will be important in developing safe, effective, and possibly curative therapy for achalasia." @default.
- W2061255909 created "2016-06-24" @default.
- W2061255909 creator A5017366543 @default.
- W2061255909 creator A5042714022 @default.
- W2061255909 date "2005-06-01" @default.
- W2061255909 modified "2023-10-06" @default.
- W2061255909 title "Etiology and Pathogenesis of Achalasia: The Current Understanding" @default.
- W2061255909 cites W116140537 @default.
- W2061255909 cites W1510514991 @default.
- W2061255909 cites W1513705320 @default.
- W2061255909 cites W1565089525 @default.
- W2061255909 cites W1593774204 @default.
- W2061255909 cites W1618395943 @default.
- W2061255909 cites W1659040565 @default.
- W2061255909 cites W1749321932 @default.
- W2061255909 cites W1787576839 @default.
- W2061255909 cites W1850353036 @default.
- W2061255909 cites W1966729916 @default.
- W2061255909 cites W1968537174 @default.
- W2061255909 cites W1969361376 @default.
- W2061255909 cites W1969892491 @default.
- W2061255909 cites W1970325888 @default.
- W2061255909 cites W1973637184 @default.
- W2061255909 cites W1975300470 @default.
- W2061255909 cites W1978027176 @default.
- W2061255909 cites W1980646177 @default.
- W2061255909 cites W1982373866 @default.
- W2061255909 cites W1984799907 @default.
- W2061255909 cites W1988601023 @default.
- W2061255909 cites W1993751184 @default.
- W2061255909 cites W2000395838 @default.
- W2061255909 cites W2002434171 @default.
- W2061255909 cites W2002439500 @default.
- W2061255909 cites W2002998971 @default.
- W2061255909 cites W2004989086 @default.
- W2061255909 cites W2007285565 @default.
- W2061255909 cites W2009564467 @default.
- W2061255909 cites W2014727525 @default.
- W2061255909 cites W2015255421 @default.
- W2061255909 cites W2017387633 @default.
- W2061255909 cites W2020222420 @default.
- W2061255909 cites W2020294044 @default.
- W2061255909 cites W2021051373 @default.
- W2061255909 cites W2026273928 @default.
- W2061255909 cites W2027740087 @default.
- W2061255909 cites W2028447174 @default.
- W2061255909 cites W2033501267 @default.
- W2061255909 cites W2040114360 @default.
- W2061255909 cites W2043824095 @default.
- W2061255909 cites W2044418116 @default.
- W2061255909 cites W2050286169 @default.
- W2061255909 cites W2056169163 @default.
- W2061255909 cites W2056470082 @default.
- W2061255909 cites W2056946458 @default.
- W2061255909 cites W2059698700 @default.
- W2061255909 cites W2063885235 @default.
- W2061255909 cites W2064703671 @default.
- W2061255909 cites W2066439907 @default.
- W2061255909 cites W2066749918 @default.
- W2061255909 cites W2069804739 @default.
- W2061255909 cites W2070113700 @default.
- W2061255909 cites W2071177002 @default.
- W2061255909 cites W2073226500 @default.
- W2061255909 cites W2075433603 @default.
- W2061255909 cites W2077127421 @default.
- W2061255909 cites W2080042480 @default.
- W2061255909 cites W2086074554 @default.
- W2061255909 cites W2086294583 @default.
- W2061255909 cites W2086857166 @default.
- W2061255909 cites W2088339671 @default.
- W2061255909 cites W2089331615 @default.
- W2061255909 cites W2093338906 @default.
- W2061255909 cites W2098039876 @default.
- W2061255909 cites W2106767153 @default.
- W2061255909 cites W2108902400 @default.
- W2061255909 cites W2123146503 @default.
- W2061255909 cites W2138289023 @default.
- W2061255909 cites W2138892332 @default.
- W2061255909 cites W2141173013 @default.
- W2061255909 cites W2142953340 @default.
- W2061255909 cites W2160735184 @default.
- W2061255909 cites W2170106893 @default.
- W2061255909 cites W2240263241 @default.
- W2061255909 cites W2318751249 @default.
- W2061255909 cites W2319932926 @default.
- W2061255909 cites W2410422169 @default.
- W2061255909 cites W4322388710 @default.
- W2061255909 cites W80019627 @default.
- W2061255909 cites W93415429 @default.
- W2061255909 doi "https://doi.org/10.1111/j.1572-0241.2005.41775.x" @default.
- W2061255909 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15929777" @default.
- W2061255909 hasPublicationYear "2005" @default.
- W2061255909 type Work @default.
- W2061255909 sameAs 2061255909 @default.
- W2061255909 citedByCount "322" @default.
- W2061255909 countsByYear W20612559092012 @default.
- W2061255909 countsByYear W20612559092013 @default.
- W2061255909 countsByYear W20612559092014 @default.