Matches in SemOpenAlex for { <https://semopenalex.org/work/W2061256506> ?p ?o ?g. }
- W2061256506 endingPage "20" @default.
- W2061256506 startingPage "1" @default.
- W2061256506 abstract "During the last decades, the effort of establishing satisfactory biomarkers for multiple sclerosis has been proven to be very difficult, due to the clinical and pathophysiological complexities of the disease. Recent knowledge acquired in the domains of genomics-immunogenetics and neuroimmunology, as well as the evolution in neuroimaging, has provided a whole new list of biomarkers. This variety, though, leads inevitably to confusion in the effort of decision making concerning strategic and individualized therapeutics. In this paper, our primary goal is to provide the reader with a list of the most important characteristics that a biomarker must possess in order to be considered as reliable. Additionally, up-to-date biomarkers are further divided into three subgroups, genetic-immunogenetic, laboratorial, and imaging. The most important representatives of each category are presented in the text and for the first time in a summarizing workable table, in a critical way, estimating their diagnostic potential and their efficacy to correlate with phenotypical expression, neuroinflammation, neurodegeneration, disability, and therapeutical response. Special attention is given to the gold standards of each category, like HLA-DRB1∗ polymorphisms, oligoclonal bands, vitamin D, and conventional and nonconventional imaging techniques. Moreover, not adequately established but quite promising, recently characterized biomarkers, like TOB-1 polymorphisms, are further discussed." @default.
- W2061256506 created "2016-06-24" @default.
- W2061256506 creator A5059851324 @default.
- W2061256506 creator A5066884594 @default.
- W2061256506 date "2013-01-01" @default.
- W2061256506 modified "2023-10-16" @default.
- W2061256506 title "Biomarkers in Multiple Sclerosis: An Up-to-Date Overview" @default.
- W2061256506 cites W1523316823 @default.
- W2061256506 cites W1528069886 @default.
- W2061256506 cites W1566384842 @default.
- W2061256506 cites W1587460175 @default.
- W2061256506 cites W1599608693 @default.
- W2061256506 cites W1964291413 @default.
- W2061256506 cites W1964421344 @default.
- W2061256506 cites W1964821351 @default.
- W2061256506 cites W1965341586 @default.
- W2061256506 cites W1966515383 @default.
- W2061256506 cites W1967904959 @default.
- W2061256506 cites W1968161957 @default.
- W2061256506 cites W1969036386 @default.
- W2061256506 cites W1972442533 @default.
- W2061256506 cites W1973428152 @default.
- W2061256506 cites W1973897310 @default.
- W2061256506 cites W1976005099 @default.
- W2061256506 cites W1977406411 @default.
- W2061256506 cites W1977600127 @default.
- W2061256506 cites W1978243650 @default.
- W2061256506 cites W1979047051 @default.
- W2061256506 cites W1979137792 @default.
- W2061256506 cites W1979144992 @default.
- W2061256506 cites W1982466574 @default.
- W2061256506 cites W1983660498 @default.
- W2061256506 cites W1984069677 @default.
- W2061256506 cites W1985004977 @default.
- W2061256506 cites W1985532156 @default.
- W2061256506 cites W1985693207 @default.
- W2061256506 cites W1985775190 @default.
- W2061256506 cites W1988409222 @default.
- W2061256506 cites W1994016305 @default.
- W2061256506 cites W1994469616 @default.
- W2061256506 cites W1994764678 @default.
- W2061256506 cites W1994966944 @default.
- W2061256506 cites W1999149549 @default.
- W2061256506 cites W1999427630 @default.
- W2061256506 cites W2000349584 @default.
- W2061256506 cites W2001267675 @default.
- W2061256506 cites W2002199145 @default.
- W2061256506 cites W2007867626 @default.
- W2061256506 cites W2009168765 @default.
- W2061256506 cites W2011247790 @default.
- W2061256506 cites W2012347097 @default.
- W2061256506 cites W2014287294 @default.
- W2061256506 cites W2015502121 @default.
- W2061256506 cites W2020458076 @default.
- W2061256506 cites W2021137788 @default.
- W2061256506 cites W2022933792 @default.
- W2061256506 cites W2027782871 @default.
- W2061256506 cites W2029505139 @default.
- W2061256506 cites W2031326324 @default.
- W2061256506 cites W2031608684 @default.
- W2061256506 cites W2031694038 @default.
- W2061256506 cites W2031967564 @default.
- W2061256506 cites W2033003111 @default.
- W2061256506 cites W2035325436 @default.
- W2061256506 cites W2037636284 @default.
- W2061256506 cites W2037651495 @default.
- W2061256506 cites W2037979244 @default.
- W2061256506 cites W2038904444 @default.
- W2061256506 cites W2039316546 @default.
- W2061256506 cites W2039493459 @default.
- W2061256506 cites W2039562300 @default.
- W2061256506 cites W2040547343 @default.
- W2061256506 cites W2044340152 @default.
- W2061256506 cites W2045683532 @default.
- W2061256506 cites W2050914686 @default.
- W2061256506 cites W2052216505 @default.
- W2061256506 cites W2053923728 @default.
- W2061256506 cites W2055553707 @default.
- W2061256506 cites W2065447898 @default.
- W2061256506 cites W2066297573 @default.
- W2061256506 cites W2066317913 @default.
- W2061256506 cites W2067527174 @default.
- W2061256506 cites W2068545991 @default.
- W2061256506 cites W2069096108 @default.
- W2061256506 cites W2074074558 @default.
- W2061256506 cites W2076141889 @default.
- W2061256506 cites W2077595625 @default.
- W2061256506 cites W2077944683 @default.
- W2061256506 cites W2081266075 @default.
- W2061256506 cites W2081712203 @default.
- W2061256506 cites W2082688434 @default.
- W2061256506 cites W2083919078 @default.
- W2061256506 cites W2084977360 @default.
- W2061256506 cites W2086966705 @default.
- W2061256506 cites W2087689292 @default.
- W2061256506 cites W2088302755 @default.
- W2061256506 cites W2089237405 @default.
- W2061256506 cites W2089828540 @default.