FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2061276185> ?p ?o ?g. }

• W2061276185 endingPage "8297" @default.
• W2061276185 startingPage "8292" @default.
• W2061276185 abstract "To investigate the function of the Grb10 adapter protein, we have generated mice in which the Grb10 gene was disrupted by a gene-trap insertion. Our experiments confirm that Grb10 is subject to genomic imprinting with the majority of Grb10 expression arising from the maternally inherited allele. Consistent with this, disruption of the maternal allele results in overgrowth of both the embryo and placenta such that mutant mice are at birth approximately 30% larger than normal. This observation establishes that Grb10 is a potent growth inhibitor. In humans, GRB10 is located at chromosome 7p11.2-p12 and has been associated with Silver-Russell syndrome, in which approximately 10% of those affected inherit both copies of chromosome 7 from their mother. Our results indicate that changes in GRB10 dosage could, in at least some cases, account for the severe growth retardation that is characteristic of Silver-Russell syndrome. Because Grb10 is a signaling protein capable of interacting with tyrosine kinase receptors, we tested genetically whether Grb10 might act downstream of insulin-like growth factor 2, a paternally expressed growth-promoting gene. The result indicates that Grb10 action is essentially independent of insulin-like growth factor 2, providing evidence that imprinting acts on at least two major fetal growth axes in a manner consistent with parent-offspring conflict theory." @default.
• W2061276185 created "2016-06-24" @default.
• W2061276185 creator A5001748796 @default.
• W2061276185 creator A5023162555 @default.
• W2061276185 creator A5057771613 @default.
• W2061276185 creator A5058574233 @default.
• W2061276185 creator A5059695474 @default.
• W2061276185 creator A5061727484 @default.
• W2061276185 date "2003-06-26" @default.
• W2061276185 modified "2023-10-08" @default.
• W2061276185 title "Disruption of the imprinted Grb10 gene leads to disproportionate overgrowth by an Igf2-independent mechanism" @default.
• W2061276185 cites W1533935872 @default.
• W2061276185 cites W1584143725 @default.
• W2061276185 cites W1769997374 @default.
• W2061276185 cites W1892165070 @default.
• W2061276185 cites W1971498717 @default.
• W2061276185 cites W1972607682 @default.
• W2061276185 cites W1973945575 @default.
• W2061276185 cites W1974057132 @default.
• W2061276185 cites W1974127834 @default.
• W2061276185 cites W1982650546 @default.
• W2061276185 cites W1983024391 @default.
• W2061276185 cites W1985467296 @default.
• W2061276185 cites W1997444325 @default.
• W2061276185 cites W1997905518 @default.
• W2061276185 cites W2001717986 @default.
• W2061276185 cites W2006844115 @default.
• W2061276185 cites W2007573212 @default.
• W2061276185 cites W2017949036 @default.
• W2061276185 cites W2022527563 @default.
• W2061276185 cites W2024153969 @default.
• W2061276185 cites W2035912798 @default.
• W2061276185 cites W2044714476 @default.
• W2061276185 cites W2045304058 @default.
• W2061276185 cites W2046462167 @default.
• W2061276185 cites W2048701533 @default.
• W2061276185 cites W2064308078 @default.
• W2061276185 cites W2071976775 @default.
• W2061276185 cites W2087221082 @default.
• W2061276185 cites W2109057676 @default.
• W2061276185 cites W2135311721 @default.
• W2061276185 cites W2153768622 @default.
• W2061276185 cites W2163035954 @default.
• W2061276185 cites W2167163651 @default.
• W2061276185 cites W2185773995 @default.
• W2061276185 cites W2576734941 @default.
• W2061276185 cites W4213185988 @default.
• W2061276185 cites W4237870161 @default.
• W2061276185 cites W50010786 @default.
• W2061276185 doi "https://doi.org/10.1073/pnas.1532175100" @default.
• W2061276185 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/166222" @default.
• W2061276185 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12829789" @default.
• W2061276185 hasPublicationYear "2003" @default.
• W2061276185 type Work @default.
• W2061276185 sameAs 2061276185 @default.
• W2061276185 citedByCount "255" @default.
• W2061276185 countsByYear W20612761852012 @default.
• W2061276185 countsByYear W20612761852013 @default.
• W2061276185 countsByYear W20612761852014 @default.
• W2061276185 countsByYear W20612761852015 @default.
• W2061276185 countsByYear W20612761852016 @default.
• W2061276185 countsByYear W20612761852017 @default.
• W2061276185 countsByYear W20612761852018 @default.
• W2061276185 countsByYear W20612761852019 @default.
• W2061276185 countsByYear W20612761852020 @default.
• W2061276185 countsByYear W20612761852021 @default.
• W2061276185 countsByYear W20612761852022 @default.
• W2061276185 countsByYear W20612761852023 @default.
• W2061276185 crossrefType "journal-article" @default.
• W2061276185 hasAuthorship W2061276185A5001748796 @default.
• W2061276185 hasAuthorship W2061276185A5023162555 @default.
• W2061276185 hasAuthorship W2061276185A5057771613 @default.
• W2061276185 hasAuthorship W2061276185A5058574233 @default.
• W2061276185 hasAuthorship W2061276185A5059695474 @default.
• W2061276185 hasAuthorship W2061276185A5061727484 @default.
• W2061276185 hasBestOaLocation W20612761851 @default.
• W2061276185 hasConcept C101544691 @default.
• W2061276185 hasConcept C104317684 @default.
• W2061276185 hasConcept C112446052 @default.
• W2061276185 hasConcept C112672928 @default.
• W2061276185 hasConcept C134018914 @default.
• W2061276185 hasConcept C150194340 @default.
• W2061276185 hasConcept C180754005 @default.
• W2061276185 hasConcept C190727270 @default.
• W2061276185 hasConcept C201492766 @default.
• W2061276185 hasConcept C2777391703 @default.
• W2061276185 hasConcept C2779234561 @default.
• W2061276185 hasConcept C2779306644 @default.
• W2061276185 hasConcept C54355233 @default.
• W2061276185 hasConcept C62478195 @default.
• W2061276185 hasConcept C82183700 @default.
• W2061276185 hasConcept C86803240 @default.
• W2061276185 hasConceptScore W2061276185C101544691 @default.
• W2061276185 hasConceptScore W2061276185C104317684 @default.
• W2061276185 hasConceptScore W2061276185C112446052 @default.
• W2061276185 hasConceptScore W2061276185C112672928 @default.
• W2061276185 hasConceptScore W2061276185C134018914 @default.
• W2061276185 hasConceptScore W2061276185C150194340 @default.

• next