Matches in SemOpenAlex for { <https://semopenalex.org/work/W2061277461> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W2061277461 endingPage "239" @default.
- W2061277461 startingPage "225" @default.
- W2061277461 abstract "The association of trisomy with advancing maternal chronological age suggests that some aspect of physiological aging is accelerated in women with trisomic pregnancies. This paper develops a quantitative theoretical model based on the hypothesis that trisomy risk is primarily a function of the size of the oocyte pool and, in particular, that risk is increased in women with accelerated rates of oocyte atresia and hence smaller pools at given chronological ages. Since the rate of oocyte atresia is a determinant of age at menopause, this hypothesis leads to the prediction that women who have had trisomic pregnancies reach menopause earlier than women who have not. We used data relating chronological age to oocyte number, trisomy and menopause to deduce the distribution of oocyte atresia rates in all women and in women with trisomic pregnancies. Given certain simplifying assumptions, we predict that associations between trisomy and age at menopause will vary with a woman's age at the time of trisomy such that trisomies at 34-43 years will be associated with a 1-3.4 year earlier onset of menopause, while trisomies at younger or older ages will have no or little association with age at menopause. This model, while vulnerable to the uncertainties that attend its assumptions, provides a testable prediction that permits separation of one aspect of physiological age from chronological age." @default.
- W2061277461 created "2016-06-24" @default.
- W2061277461 creator A5016685535 @default.
- W2061277461 creator A5089609002 @default.
- W2061277461 date "1992-04-01" @default.
- W2061277461 modified "2023-09-25" @default.
- W2061277461 title "Trisomy and age at menopause: predicted associations given a link with rate of oocyte atresia" @default.
- W2061277461 cites W173767523 @default.
- W2061277461 cites W1966649193 @default.
- W2061277461 cites W1971852368 @default.
- W2061277461 cites W1992034094 @default.
- W2061277461 cites W1997097468 @default.
- W2061277461 cites W1999187655 @default.
- W2061277461 cites W2007105838 @default.
- W2061277461 cites W2013283872 @default.
- W2061277461 cites W2026932871 @default.
- W2061277461 cites W2031250725 @default.
- W2061277461 cites W2043213270 @default.
- W2061277461 cites W2045970596 @default.
- W2061277461 cites W2338570682 @default.
- W2061277461 cites W2416711787 @default.
- W2061277461 cites W2485500180 @default.
- W2061277461 cites W4255011783 @default.
- W2061277461 doi "https://doi.org/10.1111/j.1365-3016.1992.tb00763.x" @default.
- W2061277461 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1584724" @default.
- W2061277461 hasPublicationYear "1992" @default.
- W2061277461 type Work @default.
- W2061277461 sameAs 2061277461 @default.
- W2061277461 citedByCount "22" @default.
- W2061277461 countsByYear W20612774612013 @default.
- W2061277461 countsByYear W20612774612015 @default.
- W2061277461 countsByYear W20612774612020 @default.
- W2061277461 crossrefType "journal-article" @default.
- W2061277461 hasAuthorship W2061277461A5016685535 @default.
- W2061277461 hasAuthorship W2061277461A5089609002 @default.
- W2061277461 hasConcept C118552586 @default.
- W2061277461 hasConcept C126322002 @default.
- W2061277461 hasConcept C131872663 @default.
- W2061277461 hasConcept C134018914 @default.
- W2061277461 hasConcept C144024400 @default.
- W2061277461 hasConcept C149923435 @default.
- W2061277461 hasConcept C196843134 @default.
- W2061277461 hasConcept C2776229224 @default.
- W2061277461 hasConcept C2776690073 @default.
- W2061277461 hasConcept C2778562196 @default.
- W2061277461 hasConcept C2779954681 @default.
- W2061277461 hasConcept C2781149206 @default.
- W2061277461 hasConcept C29456083 @default.
- W2061277461 hasConcept C54355233 @default.
- W2061277461 hasConcept C71924100 @default.
- W2061277461 hasConcept C86803240 @default.
- W2061277461 hasConceptScore W2061277461C118552586 @default.
- W2061277461 hasConceptScore W2061277461C126322002 @default.
- W2061277461 hasConceptScore W2061277461C131872663 @default.
- W2061277461 hasConceptScore W2061277461C134018914 @default.
- W2061277461 hasConceptScore W2061277461C144024400 @default.
- W2061277461 hasConceptScore W2061277461C149923435 @default.
- W2061277461 hasConceptScore W2061277461C196843134 @default.
- W2061277461 hasConceptScore W2061277461C2776229224 @default.
- W2061277461 hasConceptScore W2061277461C2776690073 @default.
- W2061277461 hasConceptScore W2061277461C2778562196 @default.
- W2061277461 hasConceptScore W2061277461C2779954681 @default.
- W2061277461 hasConceptScore W2061277461C2781149206 @default.
- W2061277461 hasConceptScore W2061277461C29456083 @default.
- W2061277461 hasConceptScore W2061277461C54355233 @default.
- W2061277461 hasConceptScore W2061277461C71924100 @default.
- W2061277461 hasConceptScore W2061277461C86803240 @default.
- W2061277461 hasIssue "2" @default.
- W2061277461 hasLocation W20612774611 @default.
- W2061277461 hasLocation W20612774612 @default.
- W2061277461 hasOpenAccess W2061277461 @default.
- W2061277461 hasPrimaryLocation W20612774611 @default.
- W2061277461 hasRelatedWork W2031250725 @default.
- W2061277461 hasRelatedWork W2061277461 @default.
- W2061277461 hasRelatedWork W2093271567 @default.
- W2061277461 hasRelatedWork W2136826099 @default.
- W2061277461 hasRelatedWork W2148049219 @default.
- W2061277461 hasRelatedWork W2236408432 @default.
- W2061277461 hasRelatedWork W2349192757 @default.
- W2061277461 hasRelatedWork W2356110015 @default.
- W2061277461 hasRelatedWork W2502977617 @default.
- W2061277461 hasRelatedWork W4233374150 @default.
- W2061277461 hasVolume "6" @default.
- W2061277461 isParatext "false" @default.
- W2061277461 isRetracted "false" @default.
- W2061277461 magId "2061277461" @default.
- W2061277461 workType "article" @default.