FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2061278319> ?p ?o ?g. }

• W2061278319 endingPage "1127" @default.
• W2061278319 startingPage "1119" @default.
• W2061278319 abstract "There is a need for the development of new, safe and efficacious drug therapies for the treatment of estrogen receptor (ER)-negative breast cancers. RL71 is a second-generation curcumin analog that exhibits potent cytotoxicity towards a variety of ER-negative breast cancer cells. Therefore, we have further examined the mechanism of this anticancer activity in three different ER-negative breast cancer cell lines. The mechanistic studies demonstrated that RL71 (1 µM) induced cell cycle arrest in the G2/M phase of the cell cycle. Moreover, RL71 (1 µM) caused 35% of SKBr3 cells to undergo apoptosis after 48 h and this effect was time-dependent. This correlated with an increase in cleaved caspase-3 as shown by western blotting. RL71 (1 µM) also decreased HER2/neu phosphorylation and increased p27 in SKBr3 cells. While in MDA-MB-231 and MDA-MB-468 cells RL71 (1 µM) significantly decreased Akt phosphorylation and transiently increased the stress kinases JNK1/2 and p38 MAPK. In addition, RL71 exhibited anti-angiogenic potential in vitro as it inhibited HUVEC cell migration and the ability of these cells to form tube-like networks. RL71 (8.5 mg/kg) was also orally bioavailable as it produced a peak plasma concentration of 0.405 µg/ml, 5 min after oral drug administration. Thus, our findings provide evidence that RL71 has potent anticancer activity and has potential to be further developed as a drug for the treatment of ER-negative breast cancer." @default.
• W2061278319 created "2016-06-24" @default.
• W2061278319 creator A5013583572 @default.
• W2061278319 creator A5036314502 @default.
• W2061278319 creator A5050042284 @default.
• W2061278319 creator A5078561219 @default.
• W2061278319 date "2012-06-15" @default.
• W2061278319 modified "2023-10-15" @default.
• W2061278319 title "RL71, a second-generation curcumin analog, induces apoptosis and downregulates Akt in ER-negative breast cancer cells" @default.
• W2061278319 cites W1484651778 @default.
• W2061278319 cites W1520204166 @default.
• W2061278319 cites W1964213831 @default.
• W2061278319 cites W1964578073 @default.
• W2061278319 cites W1966939722 @default.
• W2061278319 cites W1973528397 @default.
• W2061278319 cites W1975561903 @default.
• W2061278319 cites W1975770667 @default.
• W2061278319 cites W1976194786 @default.
• W2061278319 cites W1977464010 @default.
• W2061278319 cites W1977814448 @default.
• W2061278319 cites W1981813507 @default.
• W2061278319 cites W1990755763 @default.
• W2061278319 cites W1992361007 @default.
• W2061278319 cites W2004827880 @default.
• W2061278319 cites W2008111120 @default.
• W2061278319 cites W2021802866 @default.
• W2061278319 cites W2028804965 @default.
• W2061278319 cites W2031688689 @default.
• W2061278319 cites W2032531389 @default.
• W2061278319 cites W2035382976 @default.
• W2061278319 cites W2039839360 @default.
• W2061278319 cites W2043152591 @default.
• W2061278319 cites W2046452776 @default.
• W2061278319 cites W2052327609 @default.
• W2061278319 cites W2056984342 @default.
• W2061278319 cites W2057705659 @default.
• W2061278319 cites W2069056010 @default.
• W2061278319 cites W2069470172 @default.
• W2061278319 cites W2070088887 @default.
• W2061278319 cites W2073481952 @default.
• W2061278319 cites W2075103044 @default.
• W2061278319 cites W2087854103 @default.
• W2061278319 cites W2096098783 @default.
• W2061278319 cites W2109689528 @default.
• W2061278319 cites W2131111916 @default.
• W2061278319 cites W2131994307 @default.
• W2061278319 cites W2141692684 @default.
• W2061278319 cites W2143019025 @default.
• W2061278319 cites W2149643192 @default.
• W2061278319 cites W2154482038 @default.
• W2061278319 cites W2157285286 @default.
• W2061278319 cites W2162337073 @default.
• W2061278319 cites W2182665322 @default.
• W2061278319 cites W2388163742 @default.
• W2061278319 doi "https://doi.org/10.3892/ijo.2012.1521" @default.
• W2061278319 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22710975" @default.
• W2061278319 hasPublicationYear "2012" @default.
• W2061278319 type Work @default.
• W2061278319 sameAs 2061278319 @default.
• W2061278319 citedByCount "23" @default.
• W2061278319 countsByYear W20612783192012 @default.
• W2061278319 countsByYear W20612783192013 @default.
• W2061278319 countsByYear W20612783192014 @default.
• W2061278319 countsByYear W20612783192015 @default.
• W2061278319 countsByYear W20612783192016 @default.
• W2061278319 countsByYear W20612783192017 @default.
• W2061278319 countsByYear W20612783192019 @default.
• W2061278319 countsByYear W20612783192020 @default.
• W2061278319 countsByYear W20612783192022 @default.
• W2061278319 countsByYear W20612783192023 @default.
• W2061278319 crossrefType "journal-article" @default.
• W2061278319 hasAuthorship W2061278319A5013583572 @default.
• W2061278319 hasAuthorship W2061278319A5036314502 @default.
• W2061278319 hasAuthorship W2061278319A5050042284 @default.
• W2061278319 hasAuthorship W2061278319A5078561219 @default.
• W2061278319 hasBestOaLocation W20612783191 @default.
• W2061278319 hasConcept C105696609 @default.
• W2061278319 hasConcept C121608353 @default.
• W2061278319 hasConcept C126322002 @default.
• W2061278319 hasConcept C184235292 @default.
• W2061278319 hasConcept C190283241 @default.
• W2061278319 hasConcept C191560914 @default.
• W2061278319 hasConcept C2778250585 @default.
• W2061278319 hasConcept C2781018059 @default.
• W2061278319 hasConcept C29537977 @default.
• W2061278319 hasConcept C2994423619 @default.
• W2061278319 hasConcept C502942594 @default.
• W2061278319 hasConcept C530470458 @default.
• W2061278319 hasConcept C55493867 @default.
• W2061278319 hasConcept C57074206 @default.
• W2061278319 hasConcept C62112901 @default.
• W2061278319 hasConcept C71924100 @default.
• W2061278319 hasConcept C75217442 @default.
• W2061278319 hasConcept C84606932 @default.
• W2061278319 hasConcept C86803240 @default.
• W2061278319 hasConcept C95444343 @default.
• W2061278319 hasConcept C96232424 @default.
• W2061278319 hasConcept C98274493 @default.

• next