Matches in SemOpenAlex for { <https://semopenalex.org/work/W2061279346> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2061279346 abstract "Clinical trials endpoints based on magnitude of reduction in HIV-1 RNA levels provide an important complement to endpoints based on either virologic failure or a proportion of patients having HIV-1 RNA levels below a threshold value. However, reductions in HIV-1 RNA often are not completely observed, because many patients have HIV-1 RNA levels below the limit of quantification at the primary follow-up visit. The crude method of analyzing such data is to define all HIV-1 RNA levels that fall below the limit of quantification as being equal to that limit of quantification. This method is widely used even though the underestimation inherent in such a method may also lead to underestimation of treatment difference in terms of HIV-1 RNA reduction. Analyses based on Kaplan-Meier method and censored regression can be used to estimate such a reduction. When a high percentage of patients have HIV-1 RNA levels below the limit of quantification at the time of primary follow-up, which corresponds to censored observations, the Kaplan-Meier method does not always provide an estimate of the median HIV-1 RNA reduction. We discuss a statistical method to provide lower and upper limits of such median reduction or of other percentiles of reduction. We found that when the percentage of censoring is high, the censored method may overestimate the HIV-1 RNA reduction and then may also overestimate the treatment difference. Although the censored method is preferable to the crude method, when the level of censoring is high, we suggest computation of the upper and lower limits either to provide a range of potential values of HIV-1 RNA reduction or to detect overestimation by the censored method." @default.
- W2061279346 created "2016-06-24" @default.
- W2061279346 creator A5003806508 @default.
- W2061279346 creator A5047124634 @default.
- W2061279346 creator A5069099276 @default.
- W2061279346 creator A5080019749 @default.
- W2061279346 creator A5082925576 @default.
- W2061279346 date "2002-05-01" @default.
- W2061279346 modified "2023-09-23" @default.
- W2061279346 title "On the Use of Magnitude of Reduction in HIV-1 RNA in Clinical Trials: Statistical Analysis and Potential Biases" @default.
- W2061279346 cites W1997808475 @default.
- W2061279346 cites W2024385229 @default.
- W2061279346 cites W2027988283 @default.
- W2061279346 cites W2029152314 @default.
- W2061279346 cites W2048496837 @default.
- W2061279346 cites W2079948480 @default.
- W2061279346 cites W2097961569 @default.
- W2061279346 cites W2120752160 @default.
- W2061279346 cites W2150357065 @default.
- W2061279346 cites W2162114586 @default.
- W2061279346 cites W2313623892 @default.
- W2061279346 cites W2314621421 @default.
- W2061279346 cites W2337376130 @default.
- W2061279346 cites W45431457 @default.
- W2061279346 doi "https://doi.org/10.1097/00042560-200205010-00007" @default.
- W2061279346 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12048363" @default.
- W2061279346 hasPublicationYear "2002" @default.
- W2061279346 type Work @default.
- W2061279346 sameAs 2061279346 @default.
- W2061279346 citedByCount "14" @default.
- W2061279346 countsByYear W20612793462012 @default.
- W2061279346 crossrefType "journal-article" @default.
- W2061279346 hasAuthorship W2061279346A5003806508 @default.
- W2061279346 hasAuthorship W2061279346A5047124634 @default.
- W2061279346 hasAuthorship W2061279346A5069099276 @default.
- W2061279346 hasAuthorship W2061279346A5080019749 @default.
- W2061279346 hasAuthorship W2061279346A5082925576 @default.
- W2061279346 hasConcept C104317684 @default.
- W2061279346 hasConcept C10515644 @default.
- W2061279346 hasConcept C105795698 @default.
- W2061279346 hasConcept C122048520 @default.
- W2061279346 hasConcept C126322002 @default.
- W2061279346 hasConcept C137668524 @default.
- W2061279346 hasConcept C143998085 @default.
- W2061279346 hasConcept C203014093 @default.
- W2061279346 hasConcept C3013748606 @default.
- W2061279346 hasConcept C33923547 @default.
- W2061279346 hasConcept C44249647 @default.
- W2061279346 hasConcept C54355233 @default.
- W2061279346 hasConcept C67705224 @default.
- W2061279346 hasConcept C71924100 @default.
- W2061279346 hasConcept C86803240 @default.
- W2061279346 hasConceptScore W2061279346C104317684 @default.
- W2061279346 hasConceptScore W2061279346C10515644 @default.
- W2061279346 hasConceptScore W2061279346C105795698 @default.
- W2061279346 hasConceptScore W2061279346C122048520 @default.
- W2061279346 hasConceptScore W2061279346C126322002 @default.
- W2061279346 hasConceptScore W2061279346C137668524 @default.
- W2061279346 hasConceptScore W2061279346C143998085 @default.
- W2061279346 hasConceptScore W2061279346C203014093 @default.
- W2061279346 hasConceptScore W2061279346C3013748606 @default.
- W2061279346 hasConceptScore W2061279346C33923547 @default.
- W2061279346 hasConceptScore W2061279346C44249647 @default.
- W2061279346 hasConceptScore W2061279346C54355233 @default.
- W2061279346 hasConceptScore W2061279346C67705224 @default.
- W2061279346 hasConceptScore W2061279346C71924100 @default.
- W2061279346 hasConceptScore W2061279346C86803240 @default.
- W2061279346 hasLocation W20612793461 @default.
- W2061279346 hasLocation W20612793462 @default.
- W2061279346 hasOpenAccess W2061279346 @default.
- W2061279346 hasPrimaryLocation W20612793461 @default.
- W2061279346 hasRelatedWork W1965297665 @default.
- W2061279346 hasRelatedWork W1979765775 @default.
- W2061279346 hasRelatedWork W2003128095 @default.
- W2061279346 hasRelatedWork W2015525072 @default.
- W2061279346 hasRelatedWork W2062100105 @default.
- W2061279346 hasRelatedWork W2072820915 @default.
- W2061279346 hasRelatedWork W2072860251 @default.
- W2061279346 hasRelatedWork W2084195248 @default.
- W2061279346 hasRelatedWork W2094608288 @default.
- W2061279346 hasRelatedWork W2099124093 @default.
- W2061279346 hasRelatedWork W2100598547 @default.
- W2061279346 hasRelatedWork W2101064401 @default.
- W2061279346 hasRelatedWork W2129742476 @default.
- W2061279346 hasRelatedWork W2171141994 @default.
- W2061279346 hasRelatedWork W2171447259 @default.
- W2061279346 hasRelatedWork W2291988255 @default.
- W2061279346 hasRelatedWork W2314621421 @default.
- W2061279346 hasRelatedWork W2466731964 @default.
- W2061279346 hasRelatedWork W2470405094 @default.
- W2061279346 hasRelatedWork W2911611836 @default.
- W2061279346 isParatext "false" @default.
- W2061279346 isRetracted "false" @default.
- W2061279346 magId "2061279346" @default.
- W2061279346 workType "article" @default.