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- W2061311916 abstract "The aqueous extract of the tuber of Smilax china L., popularly known in China as “Jin Gang Ten”, was tested for its anti-inflammatory activities in rats by egg-albumin-induced edema and anti-nociceptive effects in mice using hot-plate test and acetic acid-induced abdominal constriction test, respectively. The aqueous extract in the dose of 1000 mg/kg (i.g.) had a significant anti-nociceptive and anti-inflammatory effect compared to physiological saline. The anti-inflammatory effects are similar to acetylsalicylic acid (200 mg/kg, i.g.). We also evaluated the aqueous extract for the inhibition of prostaglandin production (for COX-2 inhibitions) in lipopolysaccharide (LPS)-induced mouse macrophage cells. The result showed that both COX-2 activity and COX expression were inhibited by the extract. These active extracts suppressing activities warranted further studies of active principles and development of new anti-inflammatory and analgesic agents. Studies to determine correlation between chemical composition and pharmacological activity are underway." @default.
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- W2061311916 date "2006-02-01" @default.
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- W2061311916 title "Anti-inflammatory and anti-nociceptive activities of Smilax china L. aqueous extract" @default.
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- W2061311916 doi "https://doi.org/10.1016/j.jep.2005.08.004" @default.
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