Matches in SemOpenAlex for { <https://semopenalex.org/work/W2061320778> ?p ?o ?g. }
- W2061320778 endingPage "541" @default.
- W2061320778 startingPage "531" @default.
- W2061320778 abstract "To evaluate combined prophylaxis for Pneumocystis carinii pneumonia (PCP) and toxoplasmic encephalitis, 533 patients with symptomatic human immunodeficiency virus infection and/or CD4 lymphocyte counts of <200/µL were randomized to receive dapsone/pyrimethamine (200/75 mg once weekly) or aerosolized pentamidine (300 mg every 4 weeks). The median CD4 lymphocyte count was 110/µL; 47.5% were seropositive for toxoplasma antibodies. The median duration of follow-up was 483 days. In the intent-to-treat analysis, 12 cases of PCP and 14 of toxoplasmic encephalitis occurred in the dapsone/pyrimethamine group and 13 and 20 cases, respectively, in the aerosolized pentamidine group (adjusted relative risk for toxoplasmosis, 0.56; P = .10). However, only two of the 14 cases of toxoplasmic encephalitis in the dapsone/pyrimethamine group developed during actual treatment. The mortality among the two groups was similar. Dapsone/pyrimethamine was not tolerated by 30% of participants. A subanalysis of 240 matched, tolerant patients yielded a relative risk for toxoplasmosis of 0.21 (P = .014), a result favoring the use of dapsone/pyrimethamine. Dapsone/pyrimethamine was as effective as aerosolized pentamidine as prophylaxis for PCP and significantly reduced the incidence of toxoplasmic encephalitis among those participants who tolerated it." @default.
- W2061320778 created "2016-06-24" @default.
- W2061320778 creator A5001628532 @default.
- W2061320778 creator A5008023699 @default.
- W2061320778 creator A5010579766 @default.
- W2061320778 creator A5016703858 @default.
- W2061320778 creator A5021984756 @default.
- W2061320778 creator A5022393713 @default.
- W2061320778 creator A5032876625 @default.
- W2061320778 creator A5044294705 @default.
- W2061320778 creator A5045788535 @default.
- W2061320778 creator A5059386443 @default.
- W2061320778 creator A5060213700 @default.
- W2061320778 creator A5062602190 @default.
- W2061320778 creator A5072659562 @default.
- W2061320778 date "1995-03-01" @default.
- W2061320778 modified "2023-09-26" @default.
- W2061320778 title "Once-Weekly Administration of Dapsone/Pyrimethamine vs. Aerosolized Pentamidine as Combined Prophylaxis for Pneumocystis carinii Pneumonia and Toxoplasmic Encephalitis in Human Immunodeficiency Virus-Infected Patients" @default.
- W2061320778 cites W129572286 @default.
- W2061320778 cites W137040874 @default.
- W2061320778 cites W1848398988 @default.
- W2061320778 cites W185223732 @default.
- W2061320778 cites W1870778633 @default.
- W2061320778 cites W1900559920 @default.
- W2061320778 cites W1963516542 @default.
- W2061320778 cites W1964268338 @default.
- W2061320778 cites W1974881768 @default.
- W2061320778 cites W1978170893 @default.
- W2061320778 cites W1981366475 @default.
- W2061320778 cites W1985565019 @default.
- W2061320778 cites W1995791620 @default.
- W2061320778 cites W1999860991 @default.
- W2061320778 cites W2001043605 @default.
- W2061320778 cites W2006005525 @default.
- W2061320778 cites W2032660454 @default.
- W2061320778 cites W2037827450 @default.
- W2061320778 cites W2043487102 @default.
- W2061320778 cites W2045874867 @default.
- W2061320778 cites W2048530100 @default.
- W2061320778 cites W2050463570 @default.
- W2061320778 cites W2054219948 @default.
- W2061320778 cites W2057417810 @default.
- W2061320778 cites W2059707463 @default.
- W2061320778 cites W2060444571 @default.
- W2061320778 cites W2073641867 @default.
- W2061320778 cites W2076486615 @default.
- W2061320778 cites W2083817362 @default.
- W2061320778 cites W2086380193 @default.
- W2061320778 cites W2087597732 @default.
- W2061320778 cites W2093168970 @default.
- W2061320778 cites W2093411361 @default.
- W2061320778 cites W2096084005 @default.
- W2061320778 cites W2105336458 @default.
- W2061320778 cites W2125891882 @default.
- W2061320778 cites W2135444901 @default.
- W2061320778 cites W2143294512 @default.
- W2061320778 cites W2324816636 @default.
- W2061320778 cites W2326288814 @default.
- W2061320778 cites W2335153389 @default.
- W2061320778 cites W2336894756 @default.
- W2061320778 cites W2337303087 @default.
- W2061320778 cites W2338892227 @default.
- W2061320778 cites W2342351290 @default.
- W2061320778 cites W2412208497 @default.
- W2061320778 cites W2991304971 @default.
- W2061320778 doi "https://doi.org/10.1093/clinids/20.3.531" @default.
- W2061320778 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7756472" @default.
- W2061320778 hasPublicationYear "1995" @default.
- W2061320778 type Work @default.
- W2061320778 sameAs 2061320778 @default.
- W2061320778 citedByCount "56" @default.
- W2061320778 countsByYear W20613207782012 @default.
- W2061320778 countsByYear W20613207782013 @default.
- W2061320778 countsByYear W20613207782014 @default.
- W2061320778 countsByYear W20613207782015 @default.
- W2061320778 countsByYear W20613207782017 @default.
- W2061320778 countsByYear W20613207782019 @default.
- W2061320778 countsByYear W20613207782020 @default.
- W2061320778 countsByYear W20613207782022 @default.
- W2061320778 crossrefType "journal-article" @default.
- W2061320778 hasAuthorship W2061320778A5001628532 @default.
- W2061320778 hasAuthorship W2061320778A5008023699 @default.
- W2061320778 hasAuthorship W2061320778A5010579766 @default.
- W2061320778 hasAuthorship W2061320778A5016703858 @default.
- W2061320778 hasAuthorship W2061320778A5021984756 @default.
- W2061320778 hasAuthorship W2061320778A5022393713 @default.
- W2061320778 hasAuthorship W2061320778A5032876625 @default.
- W2061320778 hasAuthorship W2061320778A5044294705 @default.
- W2061320778 hasAuthorship W2061320778A5045788535 @default.
- W2061320778 hasAuthorship W2061320778A5059386443 @default.
- W2061320778 hasAuthorship W2061320778A5060213700 @default.
- W2061320778 hasAuthorship W2061320778A5062602190 @default.
- W2061320778 hasAuthorship W2061320778A5072659562 @default.
- W2061320778 hasBestOaLocation W20613207782 @default.
- W2061320778 hasConcept C126322002 @default.
- W2061320778 hasConcept C159047783 @default.
- W2061320778 hasConcept C203014093 @default.
- W2061320778 hasConcept C2522874641 @default.