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- W2061322733 abstract "Purpose.: Myeloid dendritic cells (mDCs) play an important role in autoimmune diseases. However, the role of blood CD1c+ myeloid dendritic cells 1 (mDC1s), the subset of human blood mDCs, is not well understood in noninfectious uveitis. Methods.: Fresh peripheral blood samples from human noninfectious uveitis patients (n = 32) and healthy controls (HCs) (n = 64) were stained with FITC-Lineage 1 (Lin1), PERCP-HLADR, and PE-CD1c antibodies. The levels of mDC1 were quantified by using flow cytometric analysis. Longitudinal data from patients (n = 16) were analyzed to correlate the levels of mDC1 with disease activity. Results.: Blood CD1c+ mDC1 and its subpopulation, CD1chi mDC1, were increased in uveitis patients compared with HCs. Longitudinal data demonstrated that both the CD1c+ mDC1 and CD1chi mDC1 subpopulation reflected a dynamic change in clinical uveitis activity: CD1c expression was increased in active uveitis but decreased when uveitis became inactive. Conclusions.: Given these observations, an alteration in blood CD1c+ mDC1 and the CD1chi mDC1 subpopulation could be a potential biomarker to monitor clinical uveitis activity within patients." @default.
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- W2061322733 date "2014-12-16" @default.
- W2061322733 modified "2023-09-24" @default.
- W2061322733 title "Levels of Blood CD1c+ mDC1 and CD1chi mDC1 Subpopulation Reflect Disease Activity in Noninfectious Uveitis" @default.
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- W2061322733 doi "https://doi.org/10.1167/iovs.14-15416" @default.
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