FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2061326088> ?p ?o ?g. }

• W2061326088 endingPage "414" @default.
• W2061326088 startingPage "406" @default.
• W2061326088 abstract "In pregnant sheep at 120–130 days of gestational age, a study was undertaken in order to characterize the pharmacokinetics and transplacental exchange of Ivermectin after maternal or fetal intravenous administration. Eight pregnant Suffolk Down sheep of 73.2 ± 3.7 kg body weight (bw) were surgically prepared in order to insert polyvinyl catheters in the fetal femoral artery and vein and amniotic sac. Following 48 h of recovery, the ewes were randomly assigned to two experimental groups. In group 1, (maternal injection) five ewes were treated with an intravenous bolus of 0.2 mg ivermectin/kg bw. In group 2, (fetal injection) three ewes were injected with an intravenous bolus of 1 mg of ivermectin to the fetus through a fetal femoral vein catheter. Maternal and fetal blood and amniotic fluid samples were taken before and after ivermectin administration for a period of 144 h post‐treatment. Samples were analyzed by liquid chromatography (HPLC). A computerized non‐compartmental pharmacokinetic analysis was performed and the results were compared by means of the Student t‐test. The main pharmacokinetic changes observed in the maternal compartment were increases in the volume of distribution and in the half‐life of elimination (t ½β ). A limited maternal‐fetal transfer of ivermectin was evidenced by a low fetal Cmax (1.72 ± 0.6 ng/mL) and AUC (89.1 ± 11.4 ng·h/mL). While the fetal administration of ivermectin resulted in higher values of clearance (554.1 ± 177.9 mL/kg) and lower values of t ½β (8.0 ± 1.4 h) and mean residence time (8.0 ± 2.9 h) indicating that fetal‐placental unit is highly efficient in eliminating the drug as well as limiting the transfer of ivermectin from the maternal to fetal compartment." @default.
• W2061326088 created "2016-06-24" @default.
• W2061326088 creator A5041271765 @default.
• W2061326088 creator A5042788823 @default.
• W2061326088 creator A5049544903 @default.
• W2061326088 creator A5050905954 @default.
• W2061326088 date "2008-09-30" @default.
• W2061326088 modified "2023-10-18" @default.
• W2061326088 title "Pharmacokinetics of ivermectin after maternal or fetal intravenous administration in sheep" @default.
• W2061326088 cites W113020674 @default.
• W2061326088 cites W1573131564 @default.
• W2061326088 cites W1603191666 @default.
• W2061326088 cites W1976461338 @default.
• W2061326088 cites W1976583362 @default.
• W2061326088 cites W1977584573 @default.
• W2061326088 cites W1979616735 @default.
• W2061326088 cites W1982958661 @default.
• W2061326088 cites W2003716334 @default.
• W2061326088 cites W2003874140 @default.
• W2061326088 cites W2008693534 @default.
• W2061326088 cites W2008815854 @default.
• W2061326088 cites W2021031411 @default.
• W2061326088 cites W2021191615 @default.
• W2061326088 cites W2022243311 @default.
• W2061326088 cites W2022437104 @default.
• W2061326088 cites W2022974922 @default.
• W2061326088 cites W2027342488 @default.
• W2061326088 cites W2031212137 @default.
• W2061326088 cites W2035133075 @default.
• W2061326088 cites W2041138106 @default.
• W2061326088 cites W2043338573 @default.
• W2061326088 cites W2062701690 @default.
• W2061326088 cites W2062903328 @default.
• W2061326088 cites W2071419504 @default.
• W2061326088 cites W2078514317 @default.
• W2061326088 cites W2082786623 @default.
• W2061326088 cites W2083418897 @default.
• W2061326088 cites W2088425603 @default.
• W2061326088 cites W2088814806 @default.
• W2061326088 cites W2092048794 @default.
• W2061326088 cites W2092639218 @default.
• W2061326088 cites W2096920093 @default.
• W2061326088 cites W2110712892 @default.
• W2061326088 cites W2127629590 @default.
• W2061326088 cites W2129944877 @default.
• W2061326088 cites W2131851850 @default.
• W2061326088 cites W2136564762 @default.
• W2061326088 cites W2136949831 @default.
• W2061326088 cites W2147138665 @default.
• W2061326088 cites W2310914985 @default.
• W2061326088 cites W2487098937 @default.
• W2061326088 cites W26092082 @default.
• W2061326088 cites W4232953086 @default.
• W2061326088 doi "https://doi.org/10.1111/j.1365-2885.2008.00971.x" @default.
• W2061326088 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19000259" @default.
• W2061326088 hasPublicationYear "2008" @default.
• W2061326088 type Work @default.
• W2061326088 sameAs 2061326088 @default.
• W2061326088 citedByCount "12" @default.
• W2061326088 countsByYear W20613260882013 @default.
• W2061326088 countsByYear W20613260882015 @default.
• W2061326088 countsByYear W20613260882017 @default.
• W2061326088 countsByYear W20613260882019 @default.
• W2061326088 countsByYear W20613260882020 @default.
• W2061326088 countsByYear W20613260882021 @default.
• W2061326088 crossrefType "journal-article" @default.
• W2061326088 hasAuthorship W2061326088A5041271765 @default.
• W2061326088 hasAuthorship W2061326088A5042788823 @default.
• W2061326088 hasAuthorship W2061326088A5049544903 @default.
• W2061326088 hasAuthorship W2061326088A5050905954 @default.
• W2061326088 hasConcept C112705442 @default.
• W2061326088 hasConcept C126322002 @default.
• W2061326088 hasConcept C139254425 @default.
• W2061326088 hasConcept C172680121 @default.
• W2061326088 hasConcept C22979827 @default.
• W2061326088 hasConcept C2776953305 @default.
• W2061326088 hasConcept C2777499811 @default.
• W2061326088 hasConcept C2778194526 @default.
• W2061326088 hasConcept C2778376644 @default.
• W2061326088 hasConcept C2779234561 @default.
• W2061326088 hasConcept C2779906218 @default.
• W2061326088 hasConcept C42219234 @default.
• W2061326088 hasConcept C42972112 @default.
• W2061326088 hasConcept C43376680 @default.
• W2061326088 hasConcept C54355233 @default.
• W2061326088 hasConcept C71924100 @default.
• W2061326088 hasConcept C86803240 @default.
• W2061326088 hasConcept C98274493 @default.
• W2061326088 hasConceptScore W2061326088C112705442 @default.
• W2061326088 hasConceptScore W2061326088C126322002 @default.
• W2061326088 hasConceptScore W2061326088C139254425 @default.
• W2061326088 hasConceptScore W2061326088C172680121 @default.
• W2061326088 hasConceptScore W2061326088C22979827 @default.
• W2061326088 hasConceptScore W2061326088C2776953305 @default.
• W2061326088 hasConceptScore W2061326088C2777499811 @default.
• W2061326088 hasConceptScore W2061326088C2778194526 @default.
• W2061326088 hasConceptScore W2061326088C2778376644 @default.
• W2061326088 hasConceptScore W2061326088C2779234561 @default.

• next